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The aim of the study was to evaluate the efficacy of aglepristone - a progesterone receptor blocker - in the treatment of endometritis-pyometra complex (EPC) in bitches. 12 bitches of pure and mixed breeds between 2 and 13 years of age with EPC were examined. All animals were treated according to the same pattern: aglepristone (Alizine, Virbac®) was administered at the dose of 0.33 ml/kg, s.c. on days 1, 2, 7, and 14. Additionally, the antibiotic amoxycyline (Clamoxyl, Pfizer®) was administered at the dose of 1 ml/10 kg, s.c. every 48 hours for 10 days. A complete puss mass elimination, uterus involution and improvement of clinical state were observed after 3 weeks of treatment. Progesterone concentration, that was highly increased at the beginning of treatment, decreased to low levels during its first week. The leukocyte count (WBC), alkaline phosphatase (AP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) exceeded normal values before and in the first days of treatment. These parameters improved to normal values after the first week of treatment. The recurrence of EPC was not observed in any bitch during the next 2 years. Three bitches were mated in next heats but did not get pregnant. In the present study the antigestagens therapy proved highly effective: clinical recovery and the recurrence of normal haematological and biochemical counts were observed.
The aim of this work was to investigate the efficacy of aglepristone in three different doses used to terminate pregnancy 21-24 days after mating in female cats. Cats (n = 43) were divided into three groups with 14 cats in each group and one female cat was described separately. Aglepristone was injected twice, 24 h apart. Female cats in group I received 10 mg/kg subcutaneously (sc), in group II - 12.5 mg/kg sc and in group III - 15 mg/kg. Termination of pregnancy was successful in 9 female cats (64.3%) in group I, seven of which had absorbed embryo and two aborted lifeless fetuses. Four female cats gave birth to healthy kittens between days 62 and 65 of pregnancy. The last female cat gave birth to one live kitten on day 62 of pregnancy post treatment after an ultrasound examination revealed 4 embryos. In group II pregnancy was terminated in 12 female cats (85.7%), 10 of them absorbed embryos and two aborted lifeless fetuses between days 36 and 45 of pregnancy. The remaining two gave birth to live kittens between day 62 and 64 of pregnancy. In group III pregnancy was terminated in 13 female cats (92.8%), 12 of which absorbed embryos and one aborted three lifeless fetuses. The last female cat, post treatment, gave birth to one live kitten on day 61 of pregnancy after ultrasound evaluation showed 5 embryos. This kitten died within 3 days of life. One owner gave her pregnant cat a medroxyprogesterone acetate injection, and although the female cat also receive aglepristone at a dose of 20 mg/kg, she gave birth to two live kittens. The progesterone concentrations were within reference values in the examined groups and increased after the injection of aglepristone. The results indicate that none of the doses of aglepristone used were 100% successful clinically, however the most effective dose was 15 mg/kg. Pruritus at the site of injection immediately after injection was the most common side effect noticed.
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