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1

The specificity of intracellular protein aggregation

100%

Milewski M. I., Mickle J. E., Cutting G. R.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

2

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The effect of soil particles aggregation on ion adsorption

100%

Usiarow O. G., Stawinski J., Jozefaciuk G., Swieboda R.

International Agrophysics

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1993

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tom 07

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nr 4

3

p600 stabilizes microtubules to prevent the aggregation of CaMKIIalpha during photoconductive stimulation

86%

Belzil C., Ramos T., Sanada K., Colicos M. A., Nguyen M. D.

Cellular and Molecular Biology Letters

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2014

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tom 19

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nr 3

The large microtubule-associated/Ca2+-signalling protein p600 (also known as UBR4) is required for hippocampal neuronal survival upon Ca2+ dyshomeostasis induced by glutamate treatment. During this process, p600 prevents aggregation of the Ca2+/calmodulin-dependent kinase IIα (CaMKIIα), a proxy of neuronal death, via direct binding to calmodulin in a microtubuleindependent manner. Using photoconductive stimulation coupled with live imaging of single neurons, we identified a distinct mechanism of prevention of CaMKIIα aggregation by p600. Upon direct depolarization, CaMKIIα translocates to microtubules. In the absence of p600, this translocation is interrupted in favour of a sustained self-aggregation that is prevented by the microtubule-stabilizing drug paclitaxel. Thus, during photoconductive stimulation, p600 prevents the aggregation of CaMKIIα by stabilizing microtubules. The effectiveness of this stabilization for preventing CaMKIIα aggregation during direct depolarization but not during glutamate treatment suggests a model wherein p600 has two modes of action depending on the source of cytosolic Ca2+.

4

Purification of wastewater by natural flocculants

86%

Czemierska M., Szczes A., Jarosz-Wilkolazka A.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2015

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tom 96

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nr 4

5

Effect of bed rest on the adenine nucleotides concentration in human blood platelets

86%

Buczynski A., Kedziora J., Wachowicz B., Zolynski K.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 4

The effect of immobilization in bed on metabolism and function of human blood platelet was studied. Blood platelets taken from patients with bone fractures after long term bed rest (14 days and 28 days) demonstrated significantly reduced concentration of total adenine nucleotides (after 28 days reduction about 30%). This decrease of total platelet adenine nucleotides af er immobilization in bed is probably caused by s imulation of platelet secretory process. Thrombin which released from confrol platele s 58.2%±1.5% of total adenine nucleotides liberated decreased amounfs (only 23.1 %±3.3% of total) of nucleotides from patient platelets isolated after 28 days of immobilization in bed. Loss of nucleotides from platelets was accompanied by sligh ly increased extent of platelet aggregation. It is concluded that during bed rest the reactivity of blood platelets (aggregation and release reaction) is stimulated.

6

The aggregation of amphotericin B in lipid membranes - the Monte Carlo simulation

86%

Okulski W., Gawda H.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

7

Effect of rise in intracellular Na and-or cytosolic alkalinization on the aggregation of porcine blood platelets

86%

Tomasiak M.

Applied Biology Communications. Lublin Scientific Center

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1992

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tom 02

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nr 6-7

8

Circular dichroism and aggregation studies of amyloid beta [11-28] fragment and its variants

86%

Juszczyk P., Kolodziejczyk A. S., Grzonka Z.

Acta Biochimica Polonica

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2005

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tom 52

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nr 2

Aggregation of Aβ peptides is a seminal event in Alzheimer’s disease. Detailed understanding of Aβ assembly would facilitate the targeting and design of fibrillogenesis inhibitors. Here comparative conformational and aggregation studies using CD spectroscopy and thioflavine T fluorescence assay are presented. As a model peptide, the 11–28 fragment of Aβ was used. This model peptide is known to contain the core region responsible for Aβ aggregation. The structural and aggregational behaviour of the peptide was compared with the properties of its variants corresponding to natural, clinically relevant mutants at positions 21-23 (A21G, E22K, E22G, E22Q and D23N). In HFIP (hexafluoro-2-propanol), a strong α-helix inducer, the CD spectra revealed an unexpectedly high amount of β-sheet conformation. The aggregation process of Aβ(11–28) variants provoked by water addition to HFIP was found to be consistent with a model of an α-helix-containing intermediate. The aggregation propensity of all Aβ(11–28) variants was also compared and discussed.

9

Relationship between intracellular pH and aggregation in porcine blood platelets

86%

Tomasiak M.

Applied Biology Communications. Lublin Scientific Center

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1992

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tom 02

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nr 2

10

Stability and aggregation studies of non-sonicated arsonolipid-containing vesicles

86%

Fatouros D. G., Bouropoulos N., Ioannou P. V., Antimisiaris S. G.

Cellular and Molecular Biology Letters

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2005

|

tom 10

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nr 1

11

Usefulness of polymorphic markers in exclusion of BRCA1-BRCA2 mutations in families with aggregation of breast ovarian cancers

86%

Gorski B., Debniak T., Jakubowska A., Cybulski C., Huzarski T., Byrski T., Zlowocka E., Lubinski J.

Journal of Applied Genetics

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2003

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tom 44

|

nr 3

12

Molecular dynamics simulations of phospholamban: effects of membrane, phosphorylation and aggregation

86%

Houndonougbo Y., Jas G. S., Kuczera K.

Cellular and Molecular Biology Letters

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2005

|

tom 10

|

nr Suppl.2

13

The effect of met-enkephalin on granulocyte functions in vitro

86%

Godlewski A., Brzezinski P. M.

Folia Histochemica et Cytobiologica

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1999

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tom 37

|

nr 2

14

Inhibition of collagen-induced platelet reactivity by DGEA peptide

86%

Luzak B., Golanski J., Rozalski M., Boncler M. A., Watala C.

Acta Biochimica Polonica

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2003

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tom 50

|

nr 4

Direct interactions between collagen, the most thrombogenic component of the extracellular matrix, and platelet surface membrane receptors mediate platelet adhesion and induce platelet activation and aggregation. In this process two glyco- proteins are crucial: integrin a2β1, an adhesive receptor, and GPVI, which is especially responsible for signal transduction. Specific antagonists of the collagen receptors are useful tools for investigating the complexity of platelet-collagen interactions. In this work we assessed the usefulness of DGEA peptide (Asp-Gly-Glu-Ala), the shortest collagen type I-derived motif recognised by the collagen-binding integrin a2β1, as a potential antagonist of collagen receptors. We examined platelet function using several methods including platelet adhesion under static conditions, platelet function analyser PFA-100™, whole blood electric impedance aggregometry (WBEA) and flow cytometry. We found that DGEA significantly inhibited adhesion, aggregation and release reaction of collagen activated blood platelets. The inhibitory effect of DGEA on static platelet adhesion reached sub-maximal values at millimolar inhibitor concentrations, whereas the specific blocker of a2β1 — monoclonal antibodies Gi9, when used at saturating concentrations, had only a moderate inhibitory effect on platelet adhesion. Considering that 25-30% of total collagen binding to is specific, we conclude that DGEA is a strong antagonist interfering with a variety of collagen-platelet interactions, and it can be recognised not only by the primary platelet adhesion receptor but also by other collagen receptors.

15

Aggregation of LS Rubisco in response to exposure of plants to low irradiance

72%

Grabsztunowicz M., Jackowski G.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 3

16

Issledovanie i obosnovanie parametrov lemeshno-otval'nogo kartofelekopatelja s barabannym separatorom kartofel'nogo vorokha

72%

Grusheckijj S., Firman J.

Motrol. Motoryzacja i Energetyka Rolnictwa

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2015

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tom 17

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nr 1

17

Inhibition of blood platelet adhesion by phenolics' rich fraction of Hippophae rhamnoides L. fruits

72%

Olas B., Kontek B., Szczesna M., Grabarczyk L., Stochmal A., Zuchowski J.

Journal of Physiology and Pharmacology

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2017

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tom 68

|

nr 2

18

Aggregation formation mediated anoikis resistance of BEL7402 hepatoma cells

72%

Zhang Z., Han L., Cao L., Liang X., Liu Y., Liu H., Du J., Qu Z., Zhu C., Liu S., Li H., Sun W.

Folia Histochemica et Cytobiologica

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2008

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tom 46

|

nr 3

331-336

19

The spatial distribution of pine mistletoe Viscum album ssp. austriacum (Wiesb.) Volmann in a Scots pine (Pinus sylvestris L.) stand in Central Poland

72%

Kolodziejek J., Kolodziejek A.

Polish Journal of Ecology

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2013

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tom 61

|

nr 4

The evergreen, semi-parasitic pine mistletoe, Viscum album ssp. austriacum (Wiesb.) Volmann, is one of the four subspecies of European mistletoe, Viscum album L. It is frequently encountered on Scots pine communities in Poland. Distribution of pine mistletoe in representative P. sylvestris stand from the central Poland was investigated. The host density and host size to the frequency of Viscum was verified. Within the studied area 46% out of 313 individuals of P. sylvestris trees were infected by mistletoe, among them 78% in low mistletoe infection, 17% in medium and 3% in high infection. Of 1171 infections recorded on pines, 97% were on branches, 4% on the host trunk. The mistletoe individuals had an aggregated pattern of spatial distribution which was mainly explained by the host size. Infected trees are larger than uninfected ones, on average, and within the infected tree population, trees with mistletoe had higher number of dead branches than trees with none infection. Parasitized trees were more prevalent in low-density stands than in high-density stands. Mistletoes occurred mainly on the outer brunches within trees crowns.

20

Biofilm formation as a virulence determinant of uropathogenic Escherichia coli Drplus strains

72%

Zalewska-Piatek B. M., Wilkanowicz S. I., Piatek R. J., Kur J. W.

Polish Journal of Microbiology

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2009

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tom 58

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nr 3

223-229

Urinary tract infections are the most common health problem affecting millions of people each year. Uropathogenic Escherichia coli (UPEC) strains are the major factor causing lower and upper urinary tract infections. UPEC produce several virulence factors among which are surface exposed adhesive organelles (pili/fimbriae) responsible for colonization, invasion and amplification within uroepithelial cells. The virulence of the uropathogenic E. coli Dr⁺ IH11128 is associated with Dr fimbriae belonging to the Dr family of adhesins (associated with diarrhea and urinary tract infections) and a DraD protein capping the linear fiber at the bacterial cell surface. In this study we revealed that biofilm development can be another urovirulence determinant allowing pathogenic E. coli Dr⁺ to survive within the urinary tract. E. coli strains were grown in rich or minimal media, allowed to adhere to abiotic surfaces and analyzed microscopically by staining of cells with cristal violet. We found that both Dr fimbriae and DraD, exposed at the cell surface in two forms, fimbria-assoeiated or fimbria non-associated, (DraE⁺/DraD⁺, DraE⁺/DraD⁻ or DraE⁻/DraD⁺ E. coli strains) are required for biofilm formation. Additionally, we demonstrated the biofilm formation capacity of E. coli strains deficient in the surface secretion or production of the DraE adhesin.

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The specificity of intracellular protein aggregation