Wyniki wyszukiwania

1

Polyamines as regulators of cell activation

100%

Kaminska B.

Acta Biochimica Polonica

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1993

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tom 40

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nr 3

2

The learning brain - activation during classical conditioning

88%

Kossut M., Cybulska A.

Acta Neurobiologiae Experimentalis

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2009

|

tom 69

|

nr 3

The neural bases of appetitive and aversive conditioning are different, and at various stages of learning may engage distinct cortical and subcortical networks. Using [14C]2-deoxyglucose (2-DG) autoradiography we examined brain activation in mice during classical conditioning involving stimulation of whiskers on one side of the muzzle paired with an aversive or appetitive UCS. Both variants result in modifi cation of cortical representations of vibrissae activated during the conditioning. Analysis of autoradiograms revealed that the nucleus basalis of Meynert (NBM) and ventral pallidum showed stronger labeling during appetitive training while the lateral hypothalamus (LH) and basolateral amygdala (BLA) were activated only by aversive learning. Apart from that, classicalconditioning with appetitive or aversive UCS increased 2-DG uptake in a similar set of brain structures – the posterior parietal cortex (PPC), cingulate (CG) and retrosplenial gyrus (RET), caudate nucleus (CPU) and nucleus accumbens (NA). Formation of sensory association, compared to pseudoconditioning, induces more activity in the subcortical sensory processing pathway (ventral postero-medial and posterior nuclei of the thalamus) but not in the barrel cortex. Also, conditioning contrasted with pseudoconditioning increases activity in structures important for cognitive and attentional functions (PPC, NA, CG, RET, CPU), which might provide the enhancing input necessary for memory trace formation.

3

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Activation of dendritic cells by nematode antigens during colitis

88%

Maruszewska-Cheruiyot M., Donskow-Lysoniewska K., Piechna K.

Annals of Parasitology

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2016

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tom 62

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nr Suppl.

4

A statistical procedure [CHAIN] to study protein kinase structural mechanisms

88%

Kannan N., Af N.

Cellular and Molecular Biology Letters

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2003

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tom 08

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nr 2A

5

The effect of stimulus intensity on force output in simple reaction time task in humans

88%

Jaskowski P., Rybarczyk K., Jaroszyk F., Lemanski D.

Acta Neurobiologiae Experimentalis

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1995

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tom 55

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nr 1

6

Activation of unemployed as a competitiveness factor of Ciechanow district

75%

Pajewski T.

Economic and Regional Studies

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2014

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tom 07

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nr 1

The study was devoted to the presentation of different ways to activate the unemployed in terms of increasing the competitiveness of the county. Considerations are discussed using the example of Ciechanów county. The aim of the study was to propose ways to support people out of work in the process of searching for it, which directly affects the competitiveness of the region, in this case, the Ciechanów county. In this work, it is assumed that an increase in the competitiveness of the county is affected by the district job centre in terms of activation of unemployed people. Issues associated with the activation of the unemployed have been presented on the basis of examination in district job centre in Ciechanów in 2013. The study has presented its activities carried out in order to help the unemployed to find work. On the basis of the studies one can conclude that the employment rate of people, who have benefited from various types of assistance offered by district job centre, was at a low level. It did not, however, show the ineffectiveness of these assistance variants. Low demand for workers (including those trained under district job centre) was due to a general decrease in the demand for labor from the entrepreneurs.

7

TNFalpha-induced activation of NFkappaB protects against UV-induced apoptosis specifically in p53-proficient cells

75%

Szoltysek K., Pietranek K., Kalinowska-Herok M., Pietrowska M., Kimmel M., Widlak P.

Acta Biochimica Polonica

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2008

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tom 55

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nr 4

741-748

The signaling pathways that depend on p53 or NFκB transcription factors are essential components of cellular responses to stress. In general, p53 is involved in either activation of cell cycle arrest or induction of apoptosis, while NFκB exerts mostly anti-apoptotic functions; both regulatory pathways apparently interfere with each other. Here we aimed to analyze the effects of NFκB activation on DNA damage-induced apoptosis, either p53-dependent or p53-independent, in a set of human cell lines. Four cell lines, HCT116 and RKO colon carcinoma, NCI-H1299 lung carcinoma and HL60 myeloblastoma, each of them in two congenic variants either containing or lacking transcriptionally competent p53, were used. Cells were incubated with TNFα cytokine to activate NFκB and then treated with ultraviolet or ionizing radiation to induce apoptosis, which was assessed by measurement of the sub-G1 cell fraction. We observed that treatment with TNFα resulted in a significant reduction in the frequency of apoptotic cells in UV-irradiated p53-proficient lines (with exception of the UV-resistant NCI-H1299 cells). This anti-apoptotic effect was lost when cells were pretreated with parthenolide, an inhibitor of NFκB activation. In marked contrast, TNFα-pretreatment of p53-deficient lines resulted in an increased frequency of apoptotic cells after UV irradiation (with exception of HL60 cells). Such anti- and pro-apoptotic influence of TNFα was less obvious in cells treated with ionizing radiation. The data clearly indicates functional interference of both signaling pathways upon the damage-induced apoptotic response, yet the observed effects are both cell type- and stimulus-specific.

8

Spa tourism in the Carpathians as a chance for rural areas activation

75%

Koreleski D.

Roczniki Naukowe Stowarzyszenia Ekonomistów Rolnictwa i Agrobiznesu

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2004

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tom 06

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nr 6

9

Intracellular signalling pathways in IgE-dependent mast cell activation

75%

Kopec A., Panaszek B., Fal A. M.

Archivum Immunologiae et Therapiae Experimentalis

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2006

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tom 54

|

nr 6

10

Modulation of gastric mucosal calcium channels activity by platelet-derived growth factor

75%

Slomiany B. L., Liu J., Fecete Z., Piotrowski J., Slomiany A.

Journal of Physiology and Pharmacology

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1992

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tom 43

|

nr 4

A dihydropyridine-sensitive gastric mucosal calcium channels were isolated from the solubilized epithelial cell membranes by affinity chromatography on wheat germ agglutinin. The channels following labeling the calcium antagonist receptor site with [³H]PN200-100 were reconstituted into phospholipid vesicles which exhibited active ⁴⁵Ca²⁺ uptake as evidenced by La³⁺ displacement assays. The uptake of calcium was independent of sodium and potassium gradients indicating the electroneutral nature of the process. The channels responded in a dose dependent manner to dihydropyridine calcium antagonist, PN200-110, which at 0.5/zm exerted maximal inhibitory affect of 66% on ⁴⁵Ca²⁺ uptake, while a 52% enhacement in ⁴⁵Ca²⁺ uptake occurred with a specific calcium channel activator, BAY K8644. On platelet-derived growth factor (PDGF) binding in the presence of ATP, channel protein showed an increase in tyrosine phosphorylation of 55 and 170 kDa calcium channel proteins. Such phosphorylated channels following reconstitution into vesicles displayed a 78% greater ⁴⁵Ca²⁺ uptake. The results demonstrate the importance of PDGF in the regulation of gastric mucosal calcium uptake.

11

Arabidopsis class A and B HSFs show a spectrum of transcriptional activity

75%

Czarnecka-Verner E., Gurley W. B.

Biotechnologia

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2002

|

nr 3

12

Mechanism of protein kinase B activation by insulin IGF1 revealed by specific inhibitors of the phosphoinositide 3-kinase. Significance for diabetes and cancer

75%

Hemmings B. A.

Cellular and Molecular Biology Letters

|

1998

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tom 03

|

nr 3

13

Activation and motivation of medical students for learning histoembryology

75%

Stiblar-Martincic D.

Folia Morphologica

|

1998

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tom 57

|

nr 2

14

The activation and inactivation of lysosomal and extralysosomal compartments - a simple general model

75%

Turski W. A., Zaslonka J., Szram S., Mussur M.

Cellular and Molecular Biology Letters

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2002

|

tom 07

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nr Suppl.

15

Aktywizacja spolecznosci lokalnej jako podstawa przeobrazen strukturalnych i rozwoju gospodarczego

63%

Slusarz G.

Biuletyn Informacyjno-Handlowy. Ośrodek Doradztwa Rolniczego Boguchwała

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1996

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nr 05

17-18

16

Role of epidermal growth factor receptor transactivation in the activation of cytosolic phospholipase A2 in leptin protection of salivary gland acinar cells against ethanol cytotoxicity

63%

Slomiany B. L., Slomiany A.

Journal of Physiology and Pharmacology

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2009

|

tom 60

|

nr 2

49-55

A pleiotropic hormone, leptin, secreted into saliva by the acinar cells of salivary glands is an important mediator of the processes of oral mucosal defense. Here, we report on the role of epidermal growth factor receptor (EGFR) transactivation in the signaling events that mediate leptin protection of sublingual salivary gland acinar cells against ethanol cytotoxicity. We show that the protective effect of leptin against ethanol cytotoxicity was associated with the increased EGFR protein tyrosine kinase and cytosolic phospholipase A2 (cPLA2) activity, and characterized by a marked increase in matrix metalloproteinase MMP-9 and arachidonic acid (AA) release, and PGE2 generation. The loss in countering capacity of leptin against ethanol cytotoxicity was attained with JAK inhibitor AG490, Src inhibitor PP2, and EGFR inhibitor AG1478, as well as ERK inhibitor PD98059. Moreover, the agents evoked also the inhibition in leptin-induced up-regulation in cPLA2 activity, AA release, and PGE2 generation. The changes caused by leptin in EGFR phosphorylation, MMP-9, and cPLA2 activation were susceptible to suppression by metalloprotease inhibitor GM6001, but the production of MMP-9 was not affected by EGFR inhibitor AG1478 or PKC inhibitor Ro318220. These findings point to the involvement of MMP-9 in the event of leptin-induced EGFR transactivation that results in the signaling cascade leading to cPLA2 activation and up-regulation in PGE2 generation, thus providing new insights into the mechanism of oral mucosal protection against ethanol toxicity.

17

Pituitary met-enkephalin responses to immune system activation

63%

Pierzchala-Koziec K., Zubel J., Kanitz E.

Acta Biologica Cracoviensia. Series Zoologia

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2007

|

tom 49

19-23

18

Activation of tachykinin system in the pedunculopontine tegmental nucleus suppresses hippocampal theta rhythm in urethane-anesthetized rats

63%

Leszkowicz E., Trojniar W.

Acta Neurobiologiae Experimentalis

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2005

|

tom 65

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nr 4

19

Rola spoldzielczosci wiejskiej w rozwoju wsi i rolnictwa

63%

Mierzwa D.

Zeszyty Problemowe Postępów Nauk Rolniczych

|

2006

|

tom 514

293-304

Spółdzielnie mają na celu aktywizowanie słabszych grup społecznych w procesie gospodarczym. W opracowaniu podjęto próbę określenia jakie piony spółdzielczości, spośród badanych ten cel spełniały i jaka jest ich obecna sytuacja ekonomiczna. Na podstawie zaprezentowanego materiału można stwierdzić, że spółdzielczość wiejska spełnia rolę integratora producentów, wspiera konieczne przemiany na wsi i jest czynnikiem aktywizującym społeczności lokalne.

20

Cannabinoid receptor activation inhibits cell cycle progression by modulating 14-3-3beta

63%

Jung H.-W., Park I., Ghil S.

Cellular and Molecular Biology Letters

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2014

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tom 19

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nr 3

Cannabinoids display various pharmacological activities, including tumor regression, anti-inflammatory and neuroprotective effects. To investigate the molecular mechanisms underlying the pharmacological effects of cannabinoids, we used a yeast two-hybrid system to screen a mouse brain cDNA library for proteins interacting with type 1 cannabinoid receptor (CB1R). Using the intracellular loop 3 of CB1R as bait, we identified 14-3-3β as an interacting partner of CB1R and confirmed their interaction using affinity-binding assays. 14-3-3β has been reported to induce a cell cycle delay at the G2/M phase. We tested the effects of cannabinoids on cell cycle progression in HeLa cells synchronized using a double-thymidine block-and-release protocol and found an increase in the population of G2/M phase cells. We further found that CB1R activation augmented the interaction of 14-3-3β with Wee1 and Cdc25B, and promoted phosphorylation of Cdc2 at Tyr-15. These results suggest that cannabinoids induce cell cycle delay at the G2/M phase by activating 14-3-3β.

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