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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

The location of fusion protein AUX1-YFP in a transgenic callus of Arabidopsis thaliana

100%
Fautynowicz L., Tretyn A., Wisniewska J.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2015
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tom 96
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nr 1
2

Annamycin, a novel liposomally formulated anticancer agent

100%
Priebe W., Booser D., Perez-Soler R.
Cellular and Molecular Biology Letters
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1999
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tom 04
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nr 2
3

Diversity of the plasma membrane properties of transplantable hamster melanomas with regard to the expression of P-glycoprotein

100%
Kozlowska K., Witkowski J. M., Zarzeczna M., Cichorek M.
Folia Histochemica et Cytobiologica
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1999
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tom 37
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nr 3
4

Targeting drug-efflux pumps - a pharmacoinformatic approach

86%
Pleban K., Kaiser D., Kopp S., Peer M., Chiba P., Ecker G. F.
Acta Biochimica Polonica
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2005
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tom 52
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nr 3
In line with our studies on propafenone-type inhibitors of P-glycoprotein (P-gp), we applied several methods to approach virtual screening tools for identification of new P-gp inhibitors on one hand and the molecular basis of ligand-protein interaction on the other hand. For virtual screening, a combination of autocorrelation vectors and selforganising artificial neural networks proved extremely valuable in identifying P-gp inhibitors with structurally new scaffolds. For a closer view on the binding region for propafenone-type ligands we applied a combination of pharmacophore-driven photoaffinity labeling and protein homology modeling. On LmrA, a bacterial homologue of P-gp, we were able to identify distinct regions on transmembrane helices 3, 5 and 6 which show significant changes in the labeling pattern during different steps of the catalytic cycle.
5

Cytosolic superoxide dismutase activity after photodynamic therapy, intracellular distribution of Photofrin II and hypericin, and P-glycoprotein localization in human colon adenocarcinoma

86%
Saczko J., Kulbacka J., Chwilkowska A., Pola A., Lugowski M., Marcinkowska A., Malarska A., Banas T.
Folia Histochemica et Cytobiologica
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2007
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tom 45
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nr 2
6
Content available remote

Oenothera paradoxa defatted seeds extract containing pentagalloylglucose and procyanidins potentiates the cytotoxicity of vincristine

72%
Jaszewska E., Kosmider A., Kiss A. K., Naruszewicz M.
Journal of Physiology and Pharmacology
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2010
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tom 61
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nr 5
7
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Relative profiling of L-tryptophan derivatives from selected edible mushrooms as psychoactive nutraceuticals to inhibit P-glycoprotein: a paradigm to contest blood-brain barrier

72%
Margret A. A., Mareeswari R., Kumar K. A., Jerley A. A.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2021
|
tom 102
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nr 1
8
Content available remote

St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis of rats through the induction of pregnane X receptors and/or P-glycoproteins

72%
Sehirli A. O., Cetinel S., Ozkan N., Selman S., Tetik S., Yuksel M., Dulger F. G. A.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 2
9

Evaluation of immunohistochemical expression of P-glycoprotein in neoplasms of the mammary gland in bitches

58%
Badowska-Kozakiewicz A. M., Malicka E.
Polish Journal of Veterinary Sciences
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2010
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tom 13
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nr 2
10
Content available remote

A study comparing the efficacy of antimicrobial agents versus enzyme (P-gp) inducers in the treatment of 2,4,6 trinitrobenzenesulfonic acid-induced colitis in rats

58%
Toklu H. Z., Kabasakal L., Imeryuz N., Kan B., Celikel C., Cetinel S., Orun O., Yuksel M., Dulger G. A.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 4
11

Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1

58%
Wesolowska O.
Acta Biochimica Polonica
|
2011
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tom 58
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nr 4
Multidrug resistance (MDR) of cancer cells poses a serious obstacle to successful chemotherapy. The overexpression of multispecific ATP-binding cassette transporters appears to be the main mechanism of MDR. A search for MDR-reversing agents able to sensitize resistant cells to chemotherapy is ongoing in the hope of their possible clinical use. Studies of MDR modulators, although they have not produced clinically beneficial effects yet, may greatly enrich our knowledge about MDR transporters, their specificity and mechanism of action, especially substrate and/or inhibitor recognition. In the present review, interactions of three groups of modulators: phenothiazines, flavonoids and stilbenes with both P-glycoprotein and MRP1 are discussed. Each group of compounds is likely to interact with the MDR transporters by a different mechanism. Phenothiazines probably interact with drug binding sites, but they also could indirectly affect the transporter's activity by perturbing lipid bilayers. Flavonoids mainly interact with ABC proteins within their nucleotide-binding domains, though the more hydrophobic flavonoids may bind to regions within transmembrane domains. The possible mechanism of MDR reversal by stilbenes may result from their direct interaction with the transporter (possibly within substrate recognition sites) but some indirect effects such as stilbene-induced changes in gene expression pattern and in apoptotic pathways should also be considered. Literature data as well as some of our recent results are discussed. Special emphasis is put on cases when the interactions of a given compound with both P-glycoprotein and MRP1 have been studied simultaneously.
12

The influence of intracellular idarubicin and daunorubicin levels on drug cytotoxicity in childhood acute leukemia

58%
Styczynski J., Wysocki M., Debski R., Kurylak A., Balwierz W., Rokicka-Milewska R., Matysiak M., Balcerska A., Kowalczyk J., Wachowiak J., Sonta-Jakimczyk D., Chybicka A.
Acta Biochimica Polonica
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2002
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tom 49
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nr 1
Uptake and efflux of two anthracyclines, idarubicin (IDA) and daunorubicin (DNR), was studied in childhood acute leukemia samples. A comparison of IDA and DNR transport phenomena in relation to drug cytotoxicity and expression of P-glycoprotein (PGP) was made. Intracellular content of IDA/DNR was determined by flow cytometry using the fluorescent properties of the drugs. In vitro drug cytotoxicity was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. PGP expression was analysed by flow cytometry. The uptake and efflux rates were non-significantly higher for IDA than DNR. There were no differences between three types of leukemia with respect to drug content during accumulation and retention. After correction for the cell volume, intracellular concentration of both drugs in each moment of uptake and efflux was significantly lower in relapsed ALL and AML samples in comparison with initial ALL cells. Efflux, but not uptake, of both drugs was inversely correlated with PGP expression and IDA, but not DNR, cytotoxicity. The cytotoxicity was correlated with drug accumulation for both drugs and with drug retention for IDA. In conclusion, it seems that (1) intracellular content was related to the lipophilic properties of the drugs rather than to the type of leukemia, (2) decreased intracellular concentration of both drugs might have an impact on compromised therapy results in AML and relapsed ALL children, (3) IDA presents higher cytotoxicity, which possibly might be decreased by the presence of PGP. These results might have a practical impact on the rational design of new chemotherapy protocols.
13

Molekularne podstawy odpornosci komorek nowotworowych na chemioterapeutyki, uwarunkowane zmianami w blonie plazmatycznej

51%
Kozlowska K.
Acta Biologica et Medica
|
1992
|
tom 18
79-83
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