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Tumour-associated macrophages influence canine mammary cancer stem-like cells enhancing their pro-angiogenic properties

100%

Rybicka A., Eyileten C., Taciak B., Mucha J., Majchrzak K., Hellmen E., Krol M.

Journal of Physiology and Pharmacology

2016

tom 67

nr 4

Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential

100%

Krol M., Pawlowski K. M., Skierski J., Rao N. A. S., Hellmen E., Mol J. A., Motyl T.

Journal of Physiology and Pharmacology. Supplement

2009

tom 60

nr 1

95-106

The aim of the study was to identify the genes responsible for the high growth rate and anti-apoptotic potential in selected canine mammary cancer cells. cDNA canine microarrays were used to compare the transcriptome in simple carcinoma CMT-U27 and spindle-cell tumor CMT-U309 cell lines. In CMT-U27 cell line the growth rate (shorter cell cycle), anti-apoptotic potential (higher expression of Bcl-2) was higher and spontaneous and induced apoptosis was lower. Comparison of transcriptomes revealed 333 genes which expression differed similarly. We focused on genes involved in cell proliferation, adhesion and apoptosis, and selected 29 of them. The high growth rate and anti-apoptotic potential in CMT-U27 cells was associated with enhanced expression of genes (at the level of transcripts) involved in Ca2+ signaling pathway (Calmodulin 1, 2, 3 and SPSB2) and growth hormone cellular pathway. The low-proliferative and pro-apoptotic phenotype of CMT-U309 cells was more dependent on TGFß, neuregulin 1 pathways and adhesion-related molecules.

Analysis of microRNA expression in canine mammary cancer stem-like cells indicates epigenetic regulation of transforming growth factor-beta signaling

100%

Rybicka A., Mucha J., Majchrzak K., Taciak B., Hellmen E., Motyl T., Krol M.

Journal of Physiology and Pharmacology

2015

tom 66

nr 1

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Journal of Physiology and Pharmacology. Supplement

3 Hellmen E.

3 Krol M.

2 Majchrzak K.

2 Motyl T.

2 Mucha J.

2 Rybicka A.

2 Taciak B.

1 Eyileten C.

1 Mol J. A.

1 Pawlowski K. M.

1 Rao N. A. S.

1 Skierski J.

1 2016

1 2015

1 2009

Wyniki wyszukiwania

Tumour-associated macrophages influence canine mammary cancer stem-like cells enhancing their pro-angiogenic properties

Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential

Analysis of microRNA expression in canine mammary cancer stem-like cells indicates epigenetic regulation of transforming growth factor-beta signaling