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1

Tetrahydrocannabinol may enhance natural killer cell cytotoxicity in rats

100%
Budtke P., Glac W., Tokarski J.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
It is well known that Δ9 - tetrahydrocannabinol (THC), the main active component of marijuana, exerts mainly suppressive infl uence on the immune system. Here we present data indicating that THC induce immune enhancing effects. In this study we examined the effects of small doses of THC on the natural killer cell cytotoxicity (NKCC) (51Cr – release assay) and also on the number of NK cells (identifi ed as large granular lymphocytes, LGL) (Timonen method) in the peripheral blood in rats. Animals received acute or chronic (10 days) i.p. injections of THC at the doses of 0.2 and 0.5 mg/kg. It was found that acute injection of THC signifi cantly increased NKCC after the dose of 0.2 mg/kg (+ 131 Δ%; P<0.001 vs. control and + 52 Δ%; P<0.05 vs. 0.5 mg/kg dose). After chronic exposure to THC, a signifi cant NKCC increase was observed after the dose of 0.5 mg/kg (+ 209 Δ%; P<0.001 vs. control and + 97 Δ%; P<0.01 vs. 0.2 mg/kg dose). The number of LGL remained unchanged after both acute and chronic treatment with THC. It has been reported repeatedly that the doses of over a dozen milligrams of THC suppress NKCC. These results negate the common opinion about unidirectional suppressive effects of cannabinoids on the immune system. It seems that the pharmacodynamics rule of hormesis may also concern the infl uence of THC on the immune system.
2

Electrical stimulation of the medial septal nucleus increases cytotoxic activity of NK cells in the spleen and peripheral blood in rats

64%
Plucinska K., Grembecka B., Glac W., Budtke P., Jerzemowska G., Myslinska D., Orlikowska A., Wrona D.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
The medial septal nucleus (MS) is a forebrain limbic structure involved in learning and memory mechanisms. In previous study we found that electrolytic lesion of the medial septal nucleus caused depression of the peripheral blood natural killer cell cytotoxicity (NKCC) and the leukocyte number. In the sham operated group mere insertion of electrodes into the MS evoked transient NKCC enhancement, probably resulting from mechanical MS stimulation. To check this effect in the present study, we evaluated both spleen and blood NKCC (51Cr-release assay) and large granular lymphocytes (LGL) number (a morphological method) after chronic electrical stimulation (constant current 0.1 ms duration cathodal pulses delivered at a frequency of 50 Hz during 30-min daily session for 14 consecutive days) of MS in conscious, freely moving rats (n=12). Additionally, peripheral blood leukocyte, lymphocyte and neutrophile number was mesaured. Chronic MS stimulation caused signifi cant blood NKCC augmentation and LGL number (25.86 ± 9.31% vs. 15.75 ± 4.75%, P<0.01) in comparison to the sham group (n=13). No signifi cant effect was found in the spleen (27.14 ± 9.99% vs. 28.58 ± 8.04%). A week after termination of the stimulation procedure all measured parameters returned to the baseline. The results obtained indicate that such limbic structure as medial septum enhances antitumor and antiviral function and number of NK cells.
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