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Colocalisation of glucocorticoid and 5-HT1A receptor immunoreakrivity-expressing cells in the brain structures of low and high anxiety rats

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Lebner M., Taracha E., Maciejak P., Szyndler J., Skorzewska A., Turzynska D., Sobolewska A., Wiskowska-Stanek A., Hamed A., Bidzinski A., Plaznik A.

Acta Neurobiologiae Experimentalis

2009

tom 69

nr 3

In recent years we have elaborated an animal model to examine the neurochemical background of differences in the individual responses to conditioned aversive stimuli, using the strength of a rat contextual fear test, as a discriminating variable: low responders (LR), i.e. rats with duration of a freezing response one standard error, or more, below the mean value and high responders (HR), i.e. rats with duration of a freezing response one standard error, or more, above the mean value. It was found that 1.5 h after a testing session of contextual fear test, the LR animals showed a higher density of 5-HT1A and glucocorticoid immunoreactivity-expressing cells (GRsir) in the cortical M2 area and hippocampal dentate gyrus as well as an increased number co-expressing 5-HT1A /GRs-ir in the same areas. The HR rats had a signifi cantly higher concentration of 5-HT1A and GRs-ir in the basolateral amygdala. The present data add more arguments for the neurobiological background of differences in individual responses to aversive conditioned stimuli.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Bidzinski A.

1 Hamed A.

1 Lebner M.

1 Maciejak P.

1 Plaznik A.

1 Skorzewska A.

1 Sobolewska A.

1 Szyndler J.

1 Taracha E.

1 Turzynska D.

1 Wiskowska-Stanek A.

1 2009

Wyniki wyszukiwania

Colocalisation of glucocorticoid and 5-HT1A receptor immunoreakrivity-expressing cells in the brain structures of low and high anxiety rats