Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 4

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Neurobehavioural effects of ethanol in GluR-A and GluR-C knockout mice

100%
Sanchis-Segura C., Cowen M., Sprengel R., Spanagel R.
Acta Neurobiologiae Experimentalis
|
2003
|
tom 63
|
nr 5
2
Content available remote

Role of the brain-gut axis in alcohol-related gastrointestinal diseases - what can we learn from new animal models?

100%
Siegmund S., Spanagel R., Singer M. V.
Journal of Physiology and Pharmacology. Supplement
|
2003
|
tom 54
|
nr 4
191-207
Ethanol exerts multiple actions on nearly all organs of the body, especially on the central nervous system and the gastrointestinal tract. However, little is known about the effects ethanol has on the brain-gut axis, the linkage between the central neural system and the autonomous innervation of the gastrointestinal tract. It is indisputable that ethanol consumption does affect e.g. exocrine pancreatic secretion or intestinal motility, but it is poorly understood, how alcohol consumption may disturb the brain-gut axis and how this may cause damage to gastrointestinal organs. Due to difficulties in directly assessing ethanol effects on the brain-gut axis in humans, animal models represent a versatile tool to study this topic. However, conventional animal models widely utilized in alcohol research, e.g. the Tsukamoto-French model or the Lieber-DeCarli model, do not mimic the human conditions of ethanol consumption and are therefore not suitable for studies of the brain-gut axis. Established models from other alcohol research disciplines, e.g. addiction research, are by far more applicable. Due to this reason, we have established an animal model of alcohol-dependent rats for the use in gastrointestinal alcohol research. In this model, rats are given free access to different of alcohol solutions (5% and 20% v/v) and tap water. Over time, the rats develop signs of alcohol dependence as seen in humans (e.g. deprivation effect). Organs isolated from rats exposed to this model are currently investigated in our laboratory for alcohol-related gene-regulation compared to non-alcoholic littermates. In addition, non-alcoholic components of alcoholic beverages might affect the brain-gut axis or possibly potentiate the toxicity of ethanol. In our model, commonly ingested alcoholic beverages such as beer, wine, cognac, vodka, and whisky and their non-alcoholic constituents will be tested in future animal studies.
3

Extracellular cortical serotonin and depression-related behavior in the forced swim test is influenced by interleukin-2

88%
Karrenbauer B., Mueller C., Schwarting R., Spanagel R., Pawlak C.
Acta Neurobiologiae Experimentalis
|
2009
|
tom 69
|
nr 3
It is assumed that cytokines (like interleukins) can infl uence depression and anxiety. Interleukin-2 (IL-2) is suggested to be one factor, which may mediate behavioural and neurochemical (e.g., serotonergic) features of depression in the brain. Previously, we have shown in rats that IL-2 mRNA in the striatum and prefrontal cortex is correlated with anxiety-like avoidance behaviour in an elevated plus-maze. Additionally, striatal IL-2 microinjections affected anxiety-like behaviour in a biphasic way. In the present study, we investigated the impact of systemically (i.p.) injected IL-2 (2.5 μg/kg) on serotonegic (5-HT) and dopaminergic neurotransmission in various cortical areas by in-vivo microdialysis in anaesthetised rats (Exp. 1). Furthermore, based on the serotonergic time profi le, we conducted two experiments to test for delayed (test 2 h post injection, Exp. 2) and acute (Exp. 3) behavioural effects of systemic IL-2 (0–5 μg/kg) on depression-related behaviour in a forced swim test (FST). The neurochemical results revealed that systemic IL-2 lastingly reduced extracellular 5-HT levels in the medial prefrontal (−75%), occipital (−70%), and temporal cortices (−45%). In contrast, dopamine was moderately reduced only in the medial prefrontal cortex. The functional relevance of these specifi c neurochemical changes were supported by the subsequent behavioural evaluation showing IL-2 dose-dependent effects on depression-related behaviour in the FST after delayed testing.
4

Drug-induced gene transcription and the development of addiction

76%
Rodriguez Parkitna J., Engblom D., Lemberger T., Bilbao Leis A., Spanagel R., Schutz G.
Acta Neurobiologiae Experimentalis
|
2007
|
tom 67
|
nr 3
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.