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Changes in celebrospinal fluid concentration of oxidative stress markers during chemotherapy of acute lyphoblastic leukaemia in children

100%

Protas P., Muszynska-Roslan K., Holownia A., Krawczuk-Rybak M., Braszko J.

Acta Neurobiologiae Experimentalis

2009

tom 69

nr 3

In this study we advised question whether cerebrospinal fl uid oxidative stress markers are associated with neurotoxicity of chemotherapy of acute lymphoblastic leukaemia (ALL). Examination of 38 ALL patients revealed a statistically signifi cant increase in 8-isoprostane and decrease in total antioxidative capacity during the treatment. Dynamic analysis revealed a statistically signifi cant increase in isoprostane starting on the 59th day of the treatment when the levels were highest and remained raised during all the treatment course. The mean 8-isoprostane level at the diagnosis was 9.05 ± 5.12 pg/ml, and no correlation with initial leukocytosis, organomegaly and lactate dehydrogenase level was noted. Dynamic data analysis revealed a statistically signifi cant increase in 8-isoprostane on the 59th day of the treatment (24.85 ± 26.28) and at four points during consolidation phase (17.28 ± 8.09; 22.72 ± 21.79; 24.92 ± 22.74; 32.32 ± 26.85) as compared to its level at the diagnosis (P<0.01. The mean total antioxidative capacity level at the diagnosis was (203.98 ± 15.11 μmol/l). Dynamic data analysis revealed a statistically signifi cant decrease in total antioxidative capacity on the 59th day of the treatment (189.76 ± 4.64) and at one point during consolidation phase (188.29 ± 8.46) as compared to its level at the diagnosis (P<0.05). The study suggests that standard ALL treatment may cause neurotoxicity by oxidative stress.

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Using accelerometers as a method for improving compliance with physical activity recommendations in the treatment of obesity in children. Part II. Physical activity of social and professional groups

86%

Stelmach M. J., Protas P., Tenderenda-Banasiuk E., Kuroczycka-Saniutycz E., Wasilewska A., Lemiesz M.

Health Problems of Civilization

2023

tom 17

nr 3

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Health Problems of Civilization

2 Protas P.

1 Braszko J.

1 Holownia A.

1 Krawczuk-Rybak M.

1 Kuroczycka-Saniutycz E.

1 Lemiesz M.

1 Muszynska-Roslan K.

1 Stelmach M. J.

1 Tenderenda-Banasiuk E.

1 Wasilewska A.

1 2023

1 2009

Wyniki wyszukiwania

Changes in celebrospinal fluid concentration of oxidative stress markers during chemotherapy of acute lyphoblastic leukaemia in children

Using accelerometers as a method for improving compliance with physical activity recommendations in the treatment of obesity in children. Part II. Physical activity of social and professional groups