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1

The distribution and habitats of Sanguisorba minor and S.muricata [Rosaceae] in Poland

100%
Mandecka M., Mirek Z.
Fragmenta Floristica et Geobotanica
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1996
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tom 41
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nr 2
2

Polish exsiccata of vascular plants. Index of taxa and bibliography

81%
Mandecka M., Mirek Z., Paul W.
Polish Botanical Studies. Guidebook Series
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1998
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nr 19
3-219
3

Alterations in apoptotic signaling in lymphocytes of patients in early stage of Alzheimer's disease precede massive neuronal loss in the brain

61%
Wojsiat J., Laskowska-Kaszub K., Mandecka M., Gabryelewicz T., Kuznicki J., Wojda U.
Acta Neurobiologiae Experimentalis
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2015
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tom 75
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nr Supl.
BACKGROUND AND AIMS: Alzheimer’s disease (AD) is the most common age-related dementia worldwide of unclear early pathogenesis. Mild Cognitive Impairment (MCI) represents an early AD stage, preceding massive deposition of Aβ aggregates and associated neuronal loss in the brain. Recently we demonstrated that sporadic AD (SAD) lymphoblasts show increased levels of p21 protein, the key regulator of G1/S cell cycle checkpoint and apoptosis (Bialopiotrowicz et al. 2011, Neurobiol Aging). In the current study we aimed to elucidate if p21 levels are altered early in AD, in lymphocytes of MCI patients, and to investigate the effects of p21 on the apoptotic response of SAD and MCI lymphocytes METHODS: We compared apoptotic response to 2 deoxy-D ribose (2dRib) in EBV-immortalized B-lymphoblasts from 16 patients with SAD, 17 patients with MCI and 10 age-matched healthy individuals without dementia. Apoptotic response was measured using flow cytometry assays: AnnexinV, mitochondrial membrane potential, and SubG1-phase. RESULTS: Comparing to controls, under basal conditions p21 levels assessed by immunoblotting were significantly elevated in MCI lymphoblasts, similarly as in SAD cells. 24 h after 2dRib treatment, apoptosis was higher in SAD cells than in controls, and after stimulation p21 decreased significantly in SAD and MCI cells. CONCLUSIONS: SAD lymphoblasts are significantly lessresistant to oxidative apoptotic stimuli than controls. In MCI lymphoblasts there were similar tendencies but without statistical significance. These results suggest that changes in the p21 levels and in apoptotic response in lymphocytes appear early in AD and gradually increase with the disease progression. Furthermore, our data indicate that lymphocytes may be useful for the development of new early AD diagnostic markers based on apoptotic regulatory proteins such as p21. This research was supported by the grant 2/BIOMARKAPD/ JPND/2012 and by the Nencki Institute statutory funds.
4

Paired associates learning in Alzheimer's disease, mild cognitive impairement and healthy individuals: a preliminary study

61%
Medygral J., Barcikowska M., Chodakowska-Zebrowska M., Mandecka M., Barczak A., Szelag E.
Acta Neurobiologiae Experimentalis
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2009
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tom 69
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nr 3
CANTAB Paired Associates Learning test (PAL) involves the ability to associate the stimulus (what) with its spatial location (where).There is some evidence that structures of the medial temporal lobe plays a crucial role in formation of these associations. Evidences from both lesion (in rats, monkeys, humans) and neuroimaging studies suggest that medial temporal lobes structures such as hippocampus, parahippocampal gyrus and enthorinal cortex are affected in early stages of Alzheimer’s disease (AD). These stages can be detected using PAL which is a vulnerable tool for early preclinical detection and assessment of AD. We compared the performance of PAL in 5 patient with AD, 20 Mild Cognitive Impairment patients (MCI) and 19 normal healthy controls (NC). The performance in AD group was signifi cantly lower than those from MCI and NC group. The main difference was in committed errors at more diffi cult, 6-pattern stage, where spatial location of 6 patterns had to be remembered. Moreover, in this situation the learning of pattern location in AD group was slowed down; more trials were needed to complete 6- patterns stage. In summary, these results confi rmed that PAL may be the sensitive tool in clinical diagnosis of AD. Supported by MIND no. WKP_1/1.4.3.1 /2004/11/11/52/2005/U.
5
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Assessment of nutritional status on the basis of the mini nutritional assessment (MNA) questionnaire in patients on the internal medicine ward

61%
Golabek K., Mandecka M., Chalaj A., Drozdz K., Szuba A., Regulska-Ilow B.
Roczniki Państwowego Zakładu Higieny
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2018
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tom 69
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nr 3
Background. The inadequate nutritional status of hospitalized patients leading to the malnutrition is one of the crucial clinical problems. Objective. The aim of the study was to assess nutritional status of patients on the basis of the mini nutritional assessment (MNA) questionnaire. Material and Methods. The study group included 120 patients staying on the internal medicine ward. The average age for female and male was 65±9.7 and 63±8.4 years, respectively. To assess malnutrition the anthropometric measurements and the MNA questionnaire was conducted. Results. The average MIS (Malnutrition Indicator Score) value in female and male was 25.0 ± 3.0. Among 29% of women and 18.2% of men the risk of malnutrition occurrence was noted. The incorrect values of BMI (body mass index) were observed more frequently in male compared to female (84.0% vs. 67.0%). Incorrect values of the MAC (mid arm circumference) and CC (calf circumference) were found respectively in 6.6 % and 10.5% of female and in 2.3% of male. 55.3% of women and 75% of men declared taking more than 3 prescription drugs a day. In women were observed a significantly higher deficiency of dairy products, meat, fish, or poultry as well as meals containing legume plants or eggs per week compared to men (21.0% vs. 4.5%). An insufficient daily intake of vegetables was declared by 20.4% of men and 15.8% of women. Conclusions. The occurrence of malnutrition or its risk was observed in about a quarter of studied hospitalized patients. The malnutrition was worsened by a reported loss of appetite, a significant number of drugs being taken, and inadequate nutrition among the patients.
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