Yohimbine is an indol alkaloid obtained from the root of Rauwolfia serpentina or from the bark of Pausinystalia yohimbe tree. This alkaloid is extensively used to explore the role of alpha 2 – adrenoceptors in experimental and clinical studies. Yohimbine has been predominantly used as a pharmacological tool in treatment of men’s impotence. Moreover, it was proved that yohimbine induces anxiety states and defense reactions. The amygdala is a structure in brain corresponding to the experience anxiety. It is suggested that intra-amygdalar administration of yohimbine might result in anxiogenic effect. In our experiment we have studied effects of yohimbine administration into the central nucleus of amygdala on locomotion, exploratory behavior and the noradrenergic system activity. Our study consisted of three parts: implantation of cannulas into the central nucleus of the amygdala (AMC), elevated plus maze test and biochemical analyses. We have examined the content of biogenic amines in the main emotional structures in the brain. We observed that animals preferred closed to open arms of the elevated plus maze. Additionally, the obtained data showed that changes in the concentration of noradrenaline in the AMC and hippocampus are in line with changes in the concentration of serotonin. This may confirm thesis that yohimbine has an influence on serotoninergic transmission.
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