INTRODUCTION: Craniocerebral trauma (CCT) is important problem of modern medicine and plays a dominant role in morbidity and mortality of the population. It is known the severity of CCT can be burdened by comorbid conditions, the degree of expression of which directly depends on age. AIM(S): The aim: to study the morphological features of the liver, kidneys and myocardium of mature and immature rats after diffusive CCT in the period of acute reaction to trauma (1 hour). METHOD(S): The study was conducted on 20 mature and 20 immature rats. For both groups, intact comparison groups of the corresponding age were isolated. The rats of both groups were simulated with mechanical CCT of mild severity, by free falling of the load in the parieto-occipital region of the skull. The organ blocks were prepared for microscopic examination by standard methods. RESULTS: 1 hour after the CCT in the liver of mature rats, were observed liver enlargement, vasodilatation, diapedesis hemorrhage phenomena were noted. In immature rats, the liver was of normal size, but there was focal voiding of the vessels, as well as the phenomenon of diapedesis hemorrhage. In the kidneys of mature rats, lymphohystiocytic infiltration of the glomeruli was noted, as well as diapedesis steeping of the stroma. In immature rats, the capsule of the glomerulus and their wrinkling, the foci of necrosis of the glomeruli expressed diapedesis hemorrhages at the border of the cortical and cerebral substance are observed. In the heart of mature rats, single miosymplasts are traced. Vessels of small and medium caliber are dilated and plethora. Immature rats have small foci of necrosis, located mainly under the endocardium. CONCLUSIONS: Thus, the results of the study show that in all the organs studied after CCT in the acute phase, changes in the type of hemocirculation disturbances are noted in mature rats: stasis, infiltration, dilated vessels. In immature rats, changes in the organs are more pronounced than in mature rats. Changes are mainly ischemic and necrotic. FINANCIAL SUPPORT: PhD student non-member. One-day participation (28.08.2017). Total cost: 250 PLN.
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