Administration of isofl avones present in Pueraria radix, daidzin (DAI) or puerarin (PUE), reduces ethanol intake in rodents. The paradigm showed by these compounds is probably mediated centrally, therefore an assessment of infl uence of DAI and PUE on association between alcohol consumption and changes in memory and motor functions seems to be of scientifi c importance. Ethanol “preferring” (PR) and “non-preferring” (NP) rats were treated with DAI (40 mg/ kg, p.o.) and PUE (150 mg/kg, p.o.) for 28 consecutive days and their motor activity, motor coordination, anxiety-related reactions, shortand long-term memory were assessed. It was found that DAI (23%) and PUE (52%) lowered alcohol intake in PR rats. PUE produced a facilitation effect on long- (signifi cantly) and short-term (tendency) memory in PR rats. The effects seemed to be specifi c since PUE did not affect motor activity and anxiety-related reactions and led to improvement motor coordination in PR rats. On the contrary, DAI did not change cognitive and behavioral functions in PR animals, whereas positive effect especially on short-term memory in NP rats was found. Unfortunately, DAI lowered motor activity and coordination in NP animals. In conclusion, since PUE attenuated the defi - cits of inhibitory avoidance performance induced dizocilpine (Hsieh et al. 2002), therefore its positive effect on long-term memory via NMDA receptor activation in PR rats can be considered. The study has been supported by grant N405024 32/1684.
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