Matrix metalloproteinases are a major group of enzymes regulating cell-matrix composition, which are essential for many biological processes. Matrix Metalloproteinase-9 (MMP-9) has recently emerged as an important molecule in control of extracellular proteolysis in the synaptic plasticity. Using conventional transgenesis, we have created rats with overexpression of MMP-9 limited to the neurons of the hippocampus, cerebral cortex and cerebellum (MMP-9-gene is under control of neuronal, synapsin-1 promoter). A battery of behavioral tests, including Open Field and Elevated Plus Maze tests, revealed no signifi cant difference between young transgenic and control rats. However, age-related changes in expression level of MMP-9 in wild type rats led to some dysfunctions in behavior, as we noticed differences in general activity between the transgenic and wild type rats increasing with age. The old transgenic rats demonstrated higher activity and better motor functions and coordination than controls. Moreover, the level of anxiety was decreased in the old transgenic rats in comparison with their wild type siblings. Also, the old transgenic rats showed better taste memory than wild type. These results strongly suggest that MMP-9 may have an important role in control of the behavior of animals.
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