Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

The FORMIN 2 protein is required for the remodeling of consolidated memories

100%

Sananbenesi F., Pinhero P., Rebola N., Kerimoglu C., Burkhardt S., Rizzoli S., Mulle C., Fischer A.

Acta Neurobiologiae Experimentalis

2011

tom 71

nr S

The brain has a remarkable capacity to undergo plasticity changes that are believed to underlie the acquisition, consolidation and maintenance of memory traces. To identify the molecular and cellular substrates of cognitive function is a major aim of modern neuroscience. A critical mechanism that has been implicated with neuronal plasticity is the regulation of the actin cytoskeleton. Thus, we study the role of FORMIN 2 (FMN2), a protein that regulates actin dynamics, in the adult brain of mice. Fmn2-/- mice can normally form hippocampus-dependent associative and spatial memories but display a severe failure in adapting a once acquired memory. Thus, Fmn2-/- mice show dramatic impairments in reversal learning paradigms. On the molecular and cellular levels this phenotype is explained by deregulated actin dynamics in the hippocampal striatum lucidum linked to a reduced number of synaptic vesicles per active zone and led to specific changes in the physiology of mossy fiber-CA3 synapses. Our data indicates that FMN2 at the mossy fiber-CA3 synapse is required for the fine-tuning of hippocampal memory traces.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Burkhardt S.

1 Fischer A.

1 Kerimoglu C.

1 Mulle C.

1 Pinhero P.

1 Rebola N.

1 Rizzoli S.

1 Sananbenesi F.

1 2011

Wyniki wyszukiwania

The FORMIN 2 protein is required for the remodeling of consolidated memories