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Modulation of catalase, copper and zinc in the hippocampus and the prefrontal cortex in social isolation‑induced depression in male rats

100%

Famitafreshi H., Karimian M.

Acta Neurobiologiae Experimentalis

2019

tom 79

nr 2

Depression is a chronic illness of unknown etiology. Trace elements, such as copper and zinc, and defense antioxidants, such as catalase, are important factors that determine the clinical course of brain diseases. Furthermore, altered glucose metabolism in hippocampus and prefrontal cortex has been associated with depression. Identifying factors that can precipitate depressive-like behavior is of particular importance as it can direct clinicians towards the etiology of the disease. In this study, 16 male Sprague-Dawley rats were randomly divided into two groups: socialized and socially isolated. After one week of acclimatization, animals were housed in isolation for 14 days. Rats in the social group were socialized together for 14 days. On day 15, the forced swim test was performed and blood sugar was analyzed. The brain was removed immediately for biochemical analysis. Socially isolated rats showed more pronounced depressive-like behavior in the forced swim test than socialized rats. Moreover, socially isolated rats demonstrated significantly lower copper and zinc concentrations, as well as a marked reduction in catalase activity, in both prefrontal cortex and hippocampus compared to socialized rats. Additionally, blood sugar levels were higher in socially isolated animals. Isolation causes reduction in copper and zinc levels and catalase activity, which may precipitate depressive-like behavior in these animals.

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Berberis vulgaris alleviates Levodopa-induced dyskinesia in male mice

80%

Mokarian F., Famitafreshi H., Jahromy M. H.

Herba Polonica

2018

tom 64

nr 4

Introduction: Parkinson’s disease is a chronic debilitating disease and many patients use Levodopa as a major treatment. However, this drug in long-term use causes a serious condition that is known as Levodopainduced dyskinesia (LID). Berberis vulgaris (BV) has been known to be a good potential medication for neurologic diseases such as movement disorders. The aim of this study is to investigate the usefulness of BV for LID in mice. Material and methods: In this study, 48 adult male mice were randomly divided into six groups: 1) saline group, 2) MPTP + LID, 3) MPTP + LID + BV (5 mg/kg), 4) MPTP + LID + BV (10 mg/kg), 5) MPTP + LID + BV (20 mg/kg). MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) (30 mg/kg/ day/i.p.) was used to induce Parkinson's disease and Levodopa (50 mg/kg/day/i.p.) was used to induce LID. After induction of LID, mice received intraperitoneally (i.p.) different dosages of BV for 25 days. To investigate movement disorder improvement (dyskinesia), AIMS (Abnormal Involuntary Movement Scale) and cylinder tests were used. Results: Mice that received BV at dosages of 10 and 20 mg/kg/day showed improvement in AIMS and the cylinder test. Conclusion: BV is a useful drug for treating LID. So, parkinsonian disease patients may get a beneficial effect after treatment with BV for LID.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Herba Polonica

2 Famitafreshi H.

1 Jahromy M. H.

1 Karimian M.

1 Mokarian F.

1 2019

1 2018

Wyniki wyszukiwania

Modulation of catalase, copper and zinc in the hippocampus and the prefrontal cortex in social isolation‑induced depression in male rats

Berberis vulgaris alleviates Levodopa-induced dyskinesia in male mice