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1
Content available remote

Cytochrome P-450 metabolites in renal circulation and excretion - interaction with nitric oxide [NO] system

100%
Kompanowska-Jezierska E., Kuczeriszka M.
Journal of Physiology and Pharmacology. Supplement
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2008
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tom 59
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nr 9
137-149
2

Antihypertensive effects of simultaneous ATAT2 stimulation and ATAT1 inhibition in anaesthetised rats-mediatory role of renal medullary vasodilatation?

81%
Badzynska B.1, Lipkowski A.2, Sadowski J.1, Kompanowska-Jezierska E.1 B., Lipkowski A., Sadowski J., Kompanowska-Jezierska E.
Acta Neurobiologiae Experimentalis
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2011
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tom 71
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nr 1
Angiotensin II acts as vasoconstrictor via AT1 and as a vasodilator via AT2 receptors. Selective ligands of both receptor types are needed to study their relative importance or possible interaction in the control of normal or elevated arterial blood pressure (BP); the knowledge of the role of AT2 is still limited. In this study effects of a newly synthetized (A. Lipkowski) tripeptide AT2 agonist (LKP) on BP and intrarenal haemodynamics (renal artery Transonic probe, RBF; cortical-, outer- and inner medullary laser-Doppler fluxes, CBF, OMBF, IMBF) were determined in anaesthetised Wistar rats, receiving background intravenous infusion of norepinephrine (NE) which raised BP to 130±2 mmHg and in non-pretreated spontaneously hypertensive rats (SHR). LKP infusion (120 µg/kg/h i.v.) decreased BP (-4%, p<0.01), which was associated with a 9% increases in OMBF (p<0.05) and IMBF (NS) in Wistar rats. Although NE-induced hypertension was expected to inhibit endogenous angiotensin II synthesis, additional AT1 inhibition (losartan, 1 mg/kg i.v.) further decreased BP and increased OMBF, and tended to increase RBF. In SHR LKP infusion tended to decrease BP (-3%), which was associated with nonsignificant increase in RBF and IMBF. These changes were augmented by AT1 inhibition (losartan) and reach statistical significance. The findings indicate that the levels of AT1 and AT2 activity can independently influence arterial pressure in acutely hypertensive rats. A striking association of BP decrease with an increase in medullary blood flow suggests that perfusion of the renal medulla has a direct causative role in the control of arterial pressure. Acknowledgements. We are greatly indebted to Adamed Company, Sp. z o.o. (Pieńków, Poland) for providing us with losartan. Supported by the Polish Ministry of Science and Higher Education (grant No. N N 401225634).
3
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Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats

81%
Kuczeriszka M., Badzynska B., Kompanowska-Jezierska E.
Journal of Physiology and Pharmacology. Supplement
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2006
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tom 57
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nr 11
179-185
The renal regulatory role of cytochrome P450 dependent metabolites of arachidonic acid (AA), vasodilator epoxyeicosatrienoic acids (EETs) and vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE), was examined in anaesthetised rats. We measured renal artery flow (RBF), cortical (CBF) and medullary (MBF) perfusion (laser-Doppler) and medullary tissue nitric oxide (NO, selective electrode), after non-selective inhibition of CYP-450 pathway with 1-aminobenzotriazole (ABT, 10 mg/kg i.v.) or after selective inhibition of 20-HETE synthesis with HET0016 (Taisho Co, Yoshino-cho, Japan), infused into renal artery at 0.3 mg/kg/h or into renal medulla at rates increasing from 0.15 to 1.5 mg/kg/h. ABT caused significant (by 13.7%) decrease in RBF without changing MBF. Renal arterial HET0016 increased MBF (not RBF or CBF) from 152±12 to 174±12 perfusion units (+16%, P<0.001), while medullary tissue nitric oxide was significantly increased (P<0.001). After renal medullary HET0016, renal perfusion indices were significantly higher than after HET0016 solvent (ß-cyclodextrin). Total renal blood flow seems to be under vasodilator control of EETs whereas renal medullary perfusion under tonic suppression by 20-HETE. The data document, for the first in the whole kidney studies, the functional antagonism of 20-HETE and NO.
4
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Rapid blood pressure increase after renal denervation in anaesthetized rats: interaction of oxidative stress and neuronal nitric oxide synthase

81%
Walkowska A., Vaneckova I., Sadowski J., Kompanowska-Jezierska E.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 4
5
Content available remote

Arginine and tetrahydrobiopterin supplementation in rats with salt-induced blood pressure increase: minor hypotensive effect but improvement of renal haemodynamics

61%
Kuczeriszka M., Walkowska A., Olszynski K. H., Rafalowska J., Sadowski J., Kompanowska-Jezierska E.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 2
6

Stimulation of angiotensin ATAT2 receptor fails to alleviate blood pressure (BP) increase induced by high sodium intake in normal Wistar rats

61%
Kuczeriszka M., Walkowska A., Badzynska B., Olszynski K., Lipkowski A., Kompanowska-Jezierska E.
Acta Neurobiologiae Experimentalis
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2011
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tom 71
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nr 1
Selective ligands of both Ang II receptor types are needed to study their relative importance or possible interaction in the control of normal or elevated arterial blood pressure (BP); the knowledge of the role of AT2 is still limited. We examined if a newly synthetised (A. Lipkowski) agonist of vasodilator AT2 receptors (LKP) would affect increase in BP (7 mmHg) which developed during a 10-day exposure of Wistar rats to high-salt diet (HS, 4% Na w/w). With LKP treatment (48 mg/kg/24 h orally) BP increased more (31 mm Hg) than in untreated rats. With combined treatment: LKP + AT1 receptor antagonist (oral losartan (Los), 15 mg/kg/24 h; gift from Adamed Company, Pieńków, Poland), BP increased 19 mm Hg. At the end of studies the response of the total renal blood flow (RBF, Transonic probe) and cortical blood flow (CBF, laser-Doppler superficial probe) to intrarenal infusion of acetylcholine (Ach, 5-10 µg/kg/h) or norepinephrine (NE, 10- 30 µg/kg/h) was determined. In untreated HS rats intrarenal Ach increased RBF 17%, whereas in HS+LKP and HS+LKP+Los groups it decreased RBF 1 and 2%, respectively (NS). LKP treatment did not modify decreases in RBF after NE but limited the decrease in CBF. We conclude that stimulation of AT2 receptors did not effectively oppose the increase in BP elevation, which follows increased Na intake in Wistar rats. At high AT2 activity the renal vascular bed lost its ability to dilate, which suggests a state of substantial basal vasodilation; the ability to constrict was preserved. This suggests that intrarenal microvasculature is more responsive to AT2 stimulation compared to other peripheral vessels, as it is also more responsive to stimulation of vasoconstrictor AT1 species. Supported by the Polish Ministry of Science and Higher Education (grant No. N N 401225634).
7

Consequences of the loss of the Grainyhead-like 1 gene for renal gene expression, regulation of blood pressure and heart rate in a mouse model

51%
Pawlak M., Walkowska A., Mlacki M., Pistolic J., Wrzesinski T., Benes V., Jane S. M., Wesoly J., Kompanowska-Jezierska E., Wilanowski T.
Acta Biochimica Polonica
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2015
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tom 62
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nr 2
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