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Calcium signaling networks in neural progenitor cells critically control cell division

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Rebellato P., Malmersjo S., Uhlen P.

Acta Neurobiologiae Experimentalis

2011

tom 71

nr S

The complex and diverse cell signaling cascades underlying neural progenitor cell division and differentiation remain poorly understood. Here we demonstrate that neural progenitor cells are forming calcium (Ca2+) networks in the embryonic brain that critically control cell division. This was observed in both BrdUpulsed animals and mouse embryonic stem (ES) cell-derived neural progenitors. The intracellular Ca2+ signal cascade is driven by electrical activity and influx of Ca2+-ions from the extracellular space. Mathematical cross-correlation analysis reveals more developed networks and stronger synchronicity of spontaneous Ca2+ activity in differentiated ES cells as compared to undifferentiated cells. The signaling mechanisms were independent of synaptic transmission and indicated that gap junctions where playing a major role in this signaling event. In summary, our results suggest a novel function for Ca2+ signaling networks in regulating cell division of neural progenitor cells.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Malmersjo S.

1 Rebellato P.

1 Uhlen P.

1 2011

Wyniki wyszukiwania

Calcium signaling networks in neural progenitor cells critically control cell division