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Matrix metalloproteinasa-9 increases NMDA receptor lateral diffusion

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Michaluk P., Mikasova L., Groc L., Frischknecht R., Choquet D., Kaczmarek L.

Acta Neurobiologiae Experimentalis

2009

tom 69

nr 3

Matrix metalloproteinase-9 (MMP-9) has emerged as a physiological regulator of NMDA receptor (NMDAR)-dependent synaptic plasticity and memory. The pathways by which MMP-9 affects NMDAR signaling remain, however, not well understood. Using single Quantum Dot tracking we demonstrate that MMP-9 enzymatic activity increases NR1-NMDAR surface traffi cking but has no infl uence on AMPA receptor (AMPAR) mobility. Other extracellular protease – Cathepsin G has no effect on both NMDAR and AMPAR lateral diffusion. The mechanism of MMP-9 action on NMDAR is caused neither by change in overall extracellular matrix (ECM) structure, nor by cleavage of NMDAR subunits, but by infl uence on integrinbeta 1 signaling. These fi ndings describe a new target pathway for MMP-9 action in key physiological and pathological brain processes.

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 Choquet D.

1 Frischknecht R.

1 Groc L.

1 Kaczmarek L.

1 Michaluk P.

1 Mikasova L.

1 2009

Wyniki wyszukiwania

Matrix metalloproteinasa-9 increases NMDA receptor lateral diffusion