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Molekularne mechanizmy niewydolności serca u psów

100%

Hulanicka M., Garncarz M., Parzeniecka-Jaworska M., Jank M.

Życie Weterynaryjne

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2013

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tom 88

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nr 12

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Transcriptomic profiling of peripheral blood nucleated cells in dogs with and without clinical signs of chronic mitral valve disease

88%

Garncarz M., Hulanicka M., Parzeniecka-Jaworska M., Garncarz J., Jank M.

Bulletin of the Veterinary Institute in Puławy

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2014

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tom 58

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nr 1

The aim of the study was to demonstrate differences in the gene expression of signalling pathways between healthy dogs and dogs with chronic mitral valve disease in different heart failure groups. Blood samples were collected from 49 dogs of various breeds between 1.4 and 15.2 years of age. Isolated RNA samples were analysed for quality and integrity and the gene expression profile was determined. I Tie study demonstrated that nucleated cells from peripheral blood can be used to assess the status of heart failure in dogs. Furthermore, significant differences in the expression of the genes were noticed between healthy dogs and dogs with clinical signs of chronic mitral valve disease. This is a preliminary non-invasive study showing the feasibility of genetic testing from peripheral blood nucleated cells, which at the same time has made it possible to set the future directions of genetic studies in clinical cases of canine chronic mitral valve disease.

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Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds

88%

Garncarz M., Hulanicka M., Maciejewski H., Parzeniecka-Jaworska M., Janik M.

Polish Journal of Veterinary Sciences

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2016

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tom 19

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nr 4

Studies identifying specific pathologically expressed genes have been performed on diseased myocardial tissue samples, however less invasive studies on gene expression of peripheral blood mononucleated cells give promising results. This study assessed transcriptomic data that may be used to evaluate Dachshunds with chronic mitral valve disease. Dachshunds with different stages of heart disease were compared to a control, healthy group. Microarray data analysis revealed clusters of patients with similar expression profiles. The clusters were compared to the clinical classification scheme. Unsupervised classification of the studied groups showed three clusters. Clinical and laboratory parameters of patients from the cluster 1 were in accordance with those found in patients without heart disease. Data obtained from patients from the cluster 3 were typical of advanced heart failure patients. Comparison of the cluster 1 and 3 groups revealed 1133 differentially expressed probes, 7 significantly regulated process pathways and 2 significantly regulated Ariadne Metabolic Pathways. This study may serve as a guideline for directing future research on gene expression in chronic mitral valve disease.

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Mitral regurgitation in Dachshund dogs without heart murmurs

76%

Garncarz M., Parzeniecka-Jaworska M., Hulanicka M., Jank M., Szalus-Jordanow O., Kurek A.

Journal of Veterinary Research

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2017

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tom 61

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nr 3

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Reference intervals for transthoracic echocardiographic measurements in adult Dachshunds

76%

Garncarz M., Parzeniecka-Jaworska M., Czopowicz M., Hulanicka M., Jank M., Szalus-Jordanow O.

Polish Journal of Veterinary Sciences

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2018

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tom 21

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nr 4

Ograniczanie wyników

2 Polish Journal of Veterinary Sciences

1 Bulletin of the Veterinary Institute in Puławy

1 Journal of Veterinary Research

1 Życie Weterynaryjne

5 Garncarz M.

5 Hulanicka M.

5 Parzeniecka-Jaworska M.

4 Jank M.

2 Szalus-Jordanow O.

1 Czopowicz M.

1 Garncarz J.

1 Janik M.

1 Kurek A.

1 Maciejewski H.

1 2018

1 2017

1 2016

1 2014

1 2013

Molekularne mechanizmy niewydolności serca u psów

Transcriptomic profiling of peripheral blood nucleated cells in dogs with and without clinical signs of chronic mitral valve disease

Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds

Mitral regurgitation in Dachshund dogs without heart murmurs

Reference intervals for transthoracic echocardiographic measurements in adult Dachshunds