Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 5

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Therapeutic potential of 5-HT2C receptor ligands towards cocaine addiction

100%
Filip M., Zaniewska M.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Serotonin (5-HT) neurotransmission controls the brain physiology and contributes to the etiology of many neuropsychiatric disorders. One of the key modulators of 5-HT system is the 5-HT2C receptor which regulates feeding, satiety, mood and cognition as well as underlines the mechanisms of depression, schizophrenia and addiction (Filip and Bader 2009). Among abused drugs, cocaine addiction creates serious health and legal implications in developed world while no medication is approved for the treatment of cocaine addiction. Detailed preclinical pharmacological analyses with several selective 5-HT2C receptor ligands have provided consistent proofs that these receptors contribute to cocaine acute and repeated behaviors. In general, systemic pretreatment of 5-HT2C receptor agonists attenuates, while antagonists enhance cocaine-induced psychomotor activation, reward and reinforcement as well as subjective (discriminative stimulus) effects in laboratory animals (Filip et al. 2010). 5-HT2C receptors are also important neural mediators in the circuitry underlying cocaine-seeking and -taking behaviors since their stimulation attenuated conditioned hyperactivity to cocaine and the priming effect of acute cocaine, cue- or stresscontrolled cocaine-seeking. More importantly, the inhibitory action of 5-HT2C receptor agonists on the reinstatement of cocaine seeking, when extrapolated to abstinent human addicts, suggest therapeutic potential for these drugs as pro-abstinence and anti-relapse ones. The main shortcoming of 5-HT2C receptor agonists for cocaine addiction may be their inhibitory effects in motivated behaviors (including food consumption) as found in preclinical research (Neisewander and Acosta 2007) and recent clinical trials (Smith et al. 2009). This study was supported by the statutory activity of the Institute of Pharmacology Polish Academy of Sciences (Krakow)
2

Wartości krajobrazu okolic ujścia Prosny i problemy jego ochrony

100%
Zaniweska H., Zaniewska M.
Architektura Krajobrazu. Studia i Prezentacje
|
2013
|
nr 3
3

Bi-directional interaction between nicotine and serotonin (5-HT)2C receptors - behavioural and molecular aspects

81%
Zaniewska M., Filip M., Bader M.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Recent data point to a role of serotonin (5-HT) and its receptors, mainly 5-HT2C receptor subtype, in the effects of nicotine - the key addictive component in cigarettes. Our series of studies performed on rats showed that pharmacological blockade of 5-HT2C receptors augmented the locomotor responses to acute nicotine, while activation of these receptors diminished nicotine-induced hyperactivity, the expression of behavioural sensitisation and conditioned locomotor activity as well as depression-like behaviour evoked by nicotine withdrawal. Our more recent studies demonstrated that nicotine challenge to nicotine-sensitised rats decreased [3H]mesulergine binding to 5-HT2C receptors in the prefrontal cortex, while nicotine withdrawal reduced receptor labelling in the ventral dentate gyrus and thalamic nuclei. To identify the mechanism associated with changes in radioligand binding, we analysed the pattern of 5-HT2C receptor mRNA editing (a posttranscriptional modification that may result in functionally different receptor isoforms) following repeated nicotine administration. Interestingly, our preliminary deep sequencing data showed significant decreases in 5-HT2C receptor mRNA editing in the hippocampus of nicotine-withdrawn animals. Such an alteration in editing may affect the availability of binding sites for 5-HT2C receptor radioligand and could partially explain changes in radioligand binding noted in this brain region. Taken together, our data support the existence of bi-directional interaction between 5-HT2C receptors and nicotine. Clear effects of 5-HT2C receptor agonists to ameliorate symptoms associated with nicotine dependence have been shown. On the other hand, the ability of nicotine to affect 5-HT2C receptor binding and editing has also been reported. Present data show a new direction in the search for efficient anti-nicotinic drugs and the possibility of using 5-HT2C receptor agonists as adjuncts to smoking cessation therapy.
4

Involvement of rimonabant, a cannabinoid ch1 receptor antagonist, in the behavioral effects of cocaine

61%
Zaniewska M., McCreary A. C., Wydra K., Nowak E., Filip M., Przegalinski E.
Acta Neurobiologiae Experimentalis
|
2005
|
tom 65
|
nr 3
5
Content available remote

Effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the behavioral effects of cocaine in rats

61%
Filip M., Antkiewicz-Michaluk L., Zaniewska M., Frankowska M., Golda A., Vetulani J., Przegalinski E.
Journal of Physiology and Pharmacology
|
2007
|
tom 58
|
nr 4
The efficacy of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), a member of endogenous tetrahydroisoquinolines, in cocaine- and food-maintained responding in self-administration procedures under a fixed ratio 5 schedule of reinforcement as well as in cocaine and food seeking behaviors in male Wistar rats was examined. The effects of 1MeTIQ on cocaine discrimination and on basal locomotor activity were also assessed. In rats trained to self-administered either cocaine (0.5 mg/kg/injection) paired with the cue (light+tone) or food under a fixed ratio 5 schedule of reinforcement, 1MeTIQ (25 - 50 mg/kg) dose-dependently decreased the cocaine-maintained responding, but did not alter the food-maintained responding. 1MeTIQ (25 - 50 mg/kg) decreased the cocaine seeking behavior reinstated by a noncontingent presentation of cocaine (10 mg/kg, i.p.), but altered neither behavior reinstated by a discrete cue (tone+light) nor food-induced reinstatement. In rats trained to discriminate cocaine (10 mg/kg) from saline in water-reinforced fixed ratio 20 task, pretreatment with 1MeTIQ resulted in neither substitution nor significant alterations in the cocaine (1.25 - 10 mg/kg)-induced discriminative stimulus effects. 1MeTIQ (25 - 50 mg/kg) did not produce also a significant changes in basal horizontal activity. In conclusion, our present results outline a significance of exogenously applied 1MeTIQ in attenuating drug-evoked relapses to cocaine as well as the direct rewarding properties of cocaine (that model the cocaine-induced "high"), but not cocaine subjective effects. Moreover, a dissociation between effects of 1MeTIQ on cocaine vs. food-maintained responding was demonstrated.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.