Wyniki wyszukiwania

1

Lycopene induces apoptosis by inhibiting nuclear translocation of beta-catenin in gastric cancer cells

100%

Kim M., Kim S. H., Lim J. W., Kim H.

Journal of Physiology and Pharmacology

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2019

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tom 70

|

nr 4

2

Attempted rescue of circling mice by hair cell-specific expression (Myo7a promoter) of tmie transgene

88%

Park S., Jang S., Lee J.-H., Kim S. H., Ryoo Z. Y.

Medycyna Weterynaryjna

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2017

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tom 73

|

nr 07

The spontaneous mutant circling mouse (cir/cir) is deaf and displays abnormal behavior, particularly circling and head tossing. To rescue the circling mouse phenotype, we produced transgenic mice with hair cell-specific expression of the transmembrane inner ear (tmie) gene, using the Myo7a promoter, and generated cir/cir homozygous mice carrying the transgene (cir/cir-tgMyo7a) by breeding with circling mice. The cir/cir-tgMyo7a mice still exhibited circling behavior and were unable to swim in water unlike cir/ cir-tgCMV mice and wild-type mice. An auditory brainstem response (ABR) test demonstrated that the cir/cir-tgMyo7a mice could not respond to sound. Immunohistochemical analysis showed enhanced green fluorescent protein, a marker of tmie expression, in the inner and outer hair cells of the cir/cir-tgMyo7a mice. Hair cells and spiral ganglion neurons in the cir/cir-tgMyo7a mice were recovered, but not completely. This study demonstrates that tmie transgene expression in hair cells alone could not restore wild-type hearing and behavior in circling mice.

3

Increased p63 expression in canine perianal gland tumours

76%

Kim S. H., Seung B. J., Cho S. H., Lim H. Y., Park H. M., Sur J. H.

Journal of Veterinary Research

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2018

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tom 62

|

nr 2

4

Carboxyl terminal fragment of beta-amyloid precursor protein: electrophysiological effects and cellular toxicity

76%

Fraser S. P., Bryan A. A., Diss J. K. J., Kim J. H., Kim S. H., Suh Y. H., Djamgoz M. B. A.

Cellular and Molecular Biology Letters

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1997

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tom 02

|

nr 2

Alzheimer's disease (AD) is characterized by deposition of β-amyloid (Aβ) in areas of the brain. Aβ is a metabolic fragment of the β-amyloid precursor protein (βAPP). Genetic evidence has linked βAPP to AD, and there is increasing evidence that fragments from βAPP are neurotoxic. Aβ, the main research focus, has been shown to induce depolarizing ion channel activity. Involvement of other cleaved products from βAPP are less clear. We have investigated the 105 amino acid C-terminal peptide (CT105) (containing the full sequence Aβ), an alternative fragment linked with cellular toxicity. CT105 induced non-selective ionic currents in Xenopus oocytes (a model cell used in cell signalling studies) and was toxic to oocytes and mammalian cortical neurones. These results suggest possible involvement of CT105 in inducing the neural toxicity characteristic of AD.

5

Inhibition of calpain but not caspase activity by spectrin fragments

64%

Rolius R., Antoniou C., Nazarova L. A., Kim S. H., Cobb G., Gala P., Rajaram P., Li Q., Fung L. W.-M.

Cellular and Molecular Biology Letters

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2010

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tom 15

|

nr 3

395-405

Calpains and caspases are ubiquitous cysteine proteases that are associated with a variety of cellular pathways. Calpains are involved in processes such as long term potentiation, cell motility and apoptosis, and have been shown to cleave non-erythroid (brain) α- and β-spectrin and erythroid β-spectrin. The cleavage of erythroid α-spectrin by calpain has not been reported. Caspases play an important role in the initiation and execution of apoptosis, and have been shown to cleave non-erythroid but not erythroid spectrin. We have studied the effect of spectrin fragments on calpain and caspase activities. The erythroid and non-erythroid spectrin fragments used were from the N-terminal region of α-spectrin, and C-terminal region of β-spectrin, both consisting of regions involved in spectrin tetramer formation. We observed that the all spectrin fragments exhibited a concentration-dependent inhibitory effect on calpain, but not caspase activity. It is clear that additional studies are warranted to determine the physiological significance of calpain inhibition by spectrin fragments. Our findings suggest that calpain activity is modulated by the presence of spectrin partial domains at the tetramerization site. It is not clear whether the inhibitory effect is substrate specific or is a general effect. Further studies of this inhibitory effect may lead to the identification and development of new therapeutic agents specifically for calpains, but not for caspases. Proteins/peptides with a coiled coil helical conformation should be studied for potential inhibitory effects on calpain activity.

6

Ginseng berry concentrate prevents colon cancer via cell cycle and apoptosis regulation, and inflammation-linked Th17 cell differentiation

52%

Wang C.-Z., Wan C., Luo Y., Zhang C.-F., Zhang Q.-H., Chen L., Park C. W., Kim S. H., Liu Z., Lager M., Xu M., Hou L., Yuan C.-S.

Journal of Physiology and Pharmacology

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2021

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tom 72

|

nr 2

Ograniczanie wyników

Lycopene induces apoptosis by inhibiting nuclear translocation of beta-catenin in gastric cancer cells

Attempted rescue of circling mice by hair cell-specific expression (Myo7a promoter) of tmie transgene

Increased p63 expression in canine perianal gland tumours

Carboxyl terminal fragment of beta-amyloid precursor protein: electrophysiological effects and cellular toxicity

Inhibition of calpain but not caspase activity by spectrin fragments

Ginseng berry concentrate prevents colon cancer via cell cycle and apoptosis regulation, and inflammation-linked Th17 cell differentiation