Wyniki wyszukiwania

1

Rola osi neurotrofiny/receptory neurotrofinowe w regulacji homeostazy tkanki nerwowej

100%

Pius-Sadowska E., Machalinski B.

Postępy Biologii Komórki

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2014

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tom 41

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nr 2

2

Autologous cord blood transfusion in preterm infants - could its humoral effect be the key to control prematurity-related complications? A preliminary study

51%

Kotowski M., Litwinska Z., Klos P., Pius-Sadowska E., Zagrodnik-Ulan E., Ustianowski P., Rudnicki J., Machalinski B.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 6

3

Expression of neurotrophins and their receptors in human CD34plus bone marrow cells

51%

Paczkowska E., Piecyk K., Luczkowska K., Kotowski M., Roginska D., Pius-Sadowska E., Oronowicz K., Ostrowski M., Machalinski B.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 1

4

The influence of BDNF on human umbilical cord blood stem/progenitor cells: Implications for stem cell-based therapy of neurodegenerative disorders

51%

Paczkowska E., Luczkowska K., Piecyk K., Roginska D., Pius-Sadowska E., Ustianowski P., Cesarska E., Dolegowska B., Celewicz Z., Machalinski B.

Acta Neurobiologiae Experimentalis

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2015

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tom 75

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nr 2

Umbilical cord blood (UCB)-derived stem/progenitor cells (SPCs) have demonstrated the potential to improve neurologic function in different experimental models. SPCs can survive after transplantation in the neural microenvironment and induce neuroprotection, endogenous neurogenesis by secreting a broad repertoire of trophic and immunomodulatory cytokines. In this study, the influence of brain-derived neurotrophic factor (BDNF) pre-treatment was comprehensively evaluated in a UCB-derived lineage-negative (Lin-) SPC population. UCB-derived Lin- cells were evaluated with respect to the expression of i) neuronal markers using immunofluorescence staining and ii) specific (TrkB) receptors for BDNF using flow cytometry. Next, after BDNF pre-treatment, Lin- cells were extensively assessed with respect to apoptosis using Western blotting and proliferation via BrdU incorporation. Furthermore, NT-3 expression levels in Lin- cells using RQ PCR and antioxidative enzyme activities were assessed. We demonstrated neuronal markers as well as TrkB expression in Lin- cells and the activation of the TrkB receptor by BDNF. BDNF pre-treatment diminished apoptosis in Lin- cells and influenced the proliferation of these cells. We observed significant changes in antioxidants as well as in the increased expression of NT-3 in Lin- cells following BDNF exposure. Complex global miRNA and mRNA profiling analyses using microarray technology and GSEA revealed the differential regulation of genes involved in the proliferation, gene expression, biosynthetic processes, translation, and protein targeting. Our results support the hypothesis that pre-treatment of stem/progenitor cells could be beneficial and may be used as an auxiliary strategy for improving the properties of SPCs.

5

Growth factors and their receptors derived from human amniotic cells in vitro

42%

Grzywocz Z., Pius-Sadowska E., Klos P., Gryzik M., Wasilewska D., Aleksandrowicz B., Dworczynska M., Sabalinska M., Hoser G., Machalinski B., Kawiak J.

Folia Histochemica et Cytobiologica

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2014

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tom 52

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nr 3

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Acta Neurobiologiae Experimentalis

1 Folia Histochemica et Cytobiologica

1 Postępy Biologii Komórki

5 Machalinski B.

5 Pius-Sadowska E.

2 Klos P.

2 Kotowski M.

2 Luczkowska K.

2 Paczkowska E.

2 Piecyk K.

2 Roginska D.

2 Ustianowski P.

1 Aleksandrowicz B.

1 Celewicz Z.

1 Cesarska E.

1 Dolegowska B.

1 Dworczynska M.

1 Gryzik M.

1 Grzywocz Z.

1 Hoser G.

1 Kawiak J.

1 Litwinska Z.

1 Oronowicz K.

1 Ostrowski M.

1 Rudnicki J.

1 Sabalinska M.

1 Wasilewska D.

1 Zagrodnik-Ulan E.

1 2017

1 2016

1 2015

2 2014

Rola osi neurotrofiny/receptory neurotrofinowe w regulacji homeostazy tkanki nerwowej

Autologous cord blood transfusion in preterm infants - could its humoral effect be the key to control prematurity-related complications? A preliminary study

Expression of neurotrophins and their receptors in human CD34plus bone marrow cells

The influence of BDNF on human umbilical cord blood stem/progenitor cells: Implications for stem cell-based therapy of neurodegenerative disorders

Growth factors and their receptors derived from human amniotic cells in vitro