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1

Lesions of the central nucleus of the amygdala only impair flavor aversion learning in the absence of olfactory information

100%
Aguera A. D. R., Puerto A.
Acta Neurobiologiae Experimentalis
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2015
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tom 75
|
nr 4
The amygdala is considered a crucial brain nucleus in different modalities of aversive conditioning, including flavor aversion learning (FAL). The importance attributed to the amygdala and its subnuclei has frequently depended on the different stimuli and procedures used in FAL tasks. In this study, FAL was impaired only in animals that had lesions in the central nucleus of the amygdala (CeA) area and also had their olfactory bulbs removed. However, this task was learned by neurologically intact animals, bulbectomized animals, and rats with lesions exclusively centered in the CeA area alone. These results suggest that the CeA area may be relevant in gustatory-gut associative learning but not in FAL, in which the olfactory system may counteract the deficit produced in taste-visceral convergence.
2

Concurrent TAL: aversive processing via capsaicin-sensitive vagal afferent fibres

81%
Zafra M. A., Prados M., Molina F., Puerto A.
Acta Neurobiologiae Experimentalis
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2005
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tom 65
|
nr 5
3

Tiapride prevents the aversive but not the rewarding effect induced by parabrachial electrical stimulation in a place preference task

81%
Hurtado M. M., Garcia R., Puerto A.
Acta Neurobiologiae Experimentalis
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2017
|
tom 77
|
nr 3
The parabrachial complex has been related to the processing of both rewarding and aversive signals. This pontine area is activated after the gastrointestinal administration of rewarding nutrients, in taste aversion learning, and in response to the reinforcing and aversive effects of some drugs of abuse. Electrical stimulation of this region can induce, in different animals, preference or aversion behaviors towards a place in a rectangular three‑chamber maze task. This study examined the effect of tiapride, a D2/D3 receptor antagonist, on the aversive or rewarding effects induced by electrical stimulation of the external lateral parabrachial subnucleus (NLPBe). As previously observed, administration of tiapride interrupted the aversive effect induced by NLPBe electrical stimulation. However, in contrast to the effects of dopamine antagonists on other rewarding systems, tiapride did not impair the place preference induced by NLPBe stimulation, an activation effect that is subject to tolerance. Tiapride administration also appeared to have no effect on the horizontal motor activity (crossings) of the electrically stimulated animals. We discuss the specific relevance of parabrachial reward with respect to other reinforcing brain components or systems, especially in relation to the preference effect of drugs of abuse, such as opiates, after dopamine antagonist administration.
4

Increased short‑term food intake after external lateral parabrachial subnucleus lesions in rats

81%
Aguera A. D. R., Zafra M. A., Molina F., Puerto A.
Acta Neurobiologiae Experimentalis
|
2019
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tom 79
|
nr 1
The vagus nerve and several brainstem nuclei to which it projects have been closely associated with food intake. The aim of this study was to determine the degree to which the same or different information on food intake is processed by this nerve and by one of these nuclei, the external lateral parabrachial subnucleus (LPbNe). For this purpose, we analyzed the solid and liquid food intake of Wistar rats subjected to vagal deafferentation with capsaicin or lesions of the LPbNe. Vagotomized animals consumed significantly larger amounts of solid food during the first 24 h post-surgery but not at 48, 72, or 96 h. Animals with LPbNe lesions also consumed larger amounts of liquid and solid foods but only during periods of 60 min on day 5 and 90 min on day 6 post-surgery, respectively. According to these findings, both the vagus nerve and the LPbNe appear to be involved in short-term regulation of food intake, although they participate over different time scales. These data are discussed in terms of the potential importance of the vagal-parabrachial axis in the rapid processing of nutritional information from the upper gastrointestinal tract.
5

Inhibition of natriuresis in median eminence polydipsia: Effects after intake of diets with different osmolalities and after hypertonic NaCl administration

81%
Mahia J., Bernal A., Puerto A.
Acta Neurobiologiae Experimentalis
|
2013
|
tom 73
|
nr 3
Lesions in the hypothalamic median eminence (ME) induce polydipsia and polyuria in male rats. A first experiment was designed to examine the effect of salt consumption (standard 0.25% Na+ vs. low-salt 0.04% Na+ diet) on the fluid-electrolytic balance (plasma sodium, urinary sodium excretion, urine osmolality) and water intake of ME polydipsic animals. In the first 6 h post-surgery, the natriuretic response was higher in ME-lesioned animals than in control groups. At 24 h post-surgery, however, less sodium was excreted by ME rats fed with a standard salt diet (ME/SS), despite showing no decrease in salt intake, and they evidenced an increase in plasma sodium concentration and water intake. Urine osmolality was significantly higher in control animals than in either ME-lesioned group. In experiment 2, hypertonic NaCl administration (2 ml/2M) increased the polydipsic behavior of ME-lesioned but not control rats (day 2). Animals deprived of food/salt showed a significant reduction (on day 2) in the initial (day 1) polydipsia, which increased on day 3 when the animals had access to a standard-salt diet. These results suggest that the reduced natriuretic response and the consequent sodium retention observed in ME animals may exacerbate the hydromineral imbalance of this polydipsic syndrome.
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