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1

Ocena zanieczyszczenia powietrza Magurskiego PN z zastosowaniem porostu Hypogymnia physodes

100%
Tadeusz J.
Aura
|
2013
|
nr 09
2
Content available remote

Chronic stress adaptation of the nitric oxide synthases and IL-1beta levels in brain structures and hypothalamic-pituitary-adrenal axis activity induced by homotypic stress

51%
Gadek-Michalska A., Tadeusz J., Rachwalska P., Bugajski J.
Journal of Physiology and Pharmacology
|
2015
|
tom 66
|
nr 3
3

Prior repeated stress affects HPA axis and IL-1beta responses to acute restraint

39%
Rachwalska R., Gadek-Michalska A., Szymanska M., Tadeusz J., Spyrka J., Bugajski J.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Interleukin-1ß (IL-1ß) level is modulated during multiple stress reactions in both brain structures involved in hypothalamic-pituitary-adrenal (HPA) axis regulation and peripheral systems. Multiple distinct stressors induce different IL-1ß and HPA axis responses. The purpose of the present study was to determine if the effect of prior repeated restraint stress on IL-1ß levels in prefrontal cortex, hippocampus, hypothalamus and plasma may have an impact on alterations induced in HPA-axis responses. Experiments were performed on male Wistar rats which were exposed to 10 min restraint stress twice a day for 3 days. Twentyfour hour after the last stress period rats were injected i.p. with a single dose of IL-1ß, IL-1ß receptor antagonist or saline. After rapid decapitation, trunk blood was collected and prefrontal cortex, hippocampus and hypothalamus were excised and frozen at -70°C. Total IL-1ß, ACTH and corticosterone (CORT) levels were determined in plasma using commercially available kits. Western blot analyses were performed on brain structures samples. Repeated restraint for 3 days alone substantially augmented the resting plasma levels of both IL-1ß, ACTH and CORT 24 h after the last restraint. Pretreatment with IL-1ß antagonist abolished the increase in ACTH and CORT responses to repeated stress. IL-1ß receptor antagonist also reduced the enhancement of plasma CORT level induced by 10 min stress. This suggests the selectivity of IL-1ß receptors in central and peripheral mechanisms modulating the stress-induced HPA axis responses. These results suggest that repeated stress increases IL-1ß production which activates ACTH and CORT secretion. Repeated stress also markedly enhanced IL-1ß level in brain structures involved in HPA axis regulation. The present results support the role of brain and peripheral IL-1ß in adaptation of HPA response during prolonged stress. Grant: POIG 01.01.02-12-004/09-00 financed by European Regional Development Fund.
4

Interleukin-1beta in ACTH and corticosterone secretion

39%
Tadeusz J., Gadek-Michalska A., Szymanska M., Spyrka J., Rachwalska P., Bugajski J.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
Interleukin-1ß (IL-1ß) is crucial mediator of adaptative stress response of the hypothalamic-pituitary-adrenal (HPA) axis. The potential relationship between stress and brain IL-1ß has not been elucidated. Central and systemic administration of IL-1ß enhanced HPA axis activity. We examined the role of IL-1ß in ACTH and corticosterone (CORT) secretion and parallel alterations of IL-1ß in plasma and brain structures involved in HPA axis regulation. Experiments were performed on male Wistar rats. Non-stressed groups of rats were injected i.p. IL-1ß, IL-1ß receptor antagonist and saline. Stressed rats were exposed to 10 min restraint twice a day for 3 days. Twenty-four hour after the last stress period rats were treated like non-stressed. After decapitation trunk blood was collected and the brain prefrontal cortex, hippocampus and hypothalamus were excised and frozen at -70°C. Total CORT, ACTH and IL-1ß levels were determined using commercially available kits. Western blot analyses were performed on brain structures. Under basal conditions IL-1ß considerably increased plasma IL-1ß level, in a time dependent manner, more potently 1 h than 2 h following administration. By contrast plasma ACTH and CORT levels were more strongly enhanced at 2 h than 1 h after IL-1ß injection. This indicates that the most potent increase in plasma IL-1ß levels preceded a similar enhancement of ACTH and CORT secretion. IL-1ß receptor antagonist abolished the increase in ACTH and CORT responses to exogenous IL-1ß. Prior repeated stress increased IL-1ß production and sensitized ACTH and CORT responses to exogenous IL-1ß. Repeated stress also enhanced IL-1ß level in brain structures involved in HPA axis regulation and intensified this increase induced by exogenous IL-1ß. These results indicate the selective modulatory role of IL-1ß in HPA axis activation under basal and stress conditions. Financed by European Regional Development Fund, grant POIG 01.01.02-12-004/09-00.
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