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INTRODUCTION: Numerous studies indicate that Attention Deficit/Hyperactivity Disorder (ADHD) is related to some developmental trends, as its symptoms change widely over time. There is a disagreement whether ADHD is related to deviations in brain development or to a delay in brain maturation. The model of deviated brain development suggests that the ADHD brain matures in a fundamentally different way, and does not reach normal maturity at any developmental stage. In contrast, the delayed brain maturation model assumes that the ADHD brain indeed matures in a different, delayed way in comparison to healthy age-matched controls, yet eventually reaches proper maturation. AIM(S): We investigated developmental changes in resting‑state EEG activity to find evidence supporting one of the alternative models. METHOD(S): A total number of 141 participants took part in the study: 67 ADHD and 74 healthy controls. We recorded 5 minutes of resting-state EEG. Each participant’s power estimates were averaged across clusters of electrodes and across frequency bands: delta, theta, alpha, and beta. The absolute power of each frequency was analyzed. To test the combined effect of age and ADHD diagnosis on EEG power spectrum, we performed a regression analysis. RESULTS: The results revealed a typical developmental effect of decreasing absolute EEG power with increasing age. Absolute EEG power was found to decrease linearly especially for delta and theta frequencies in both groups. We also observed differences between groups. The ADHD group had significantly lower absolute power in all frequency bands, with the most pronounced difference in lower theta absolute power. CONCLUSIONS: This study revealed that the resting-EEG developmental pattern was similar in ADHD and healthy controls. Even so, the ADHD group had consistently lower absolute EEG power, mostly in the theta frequency band. Our results are in line with deviant brain maturation hypothesis, as ADHD brain activity would not be considered the same as in healthy controls at any age. FINANCIAL SUPPORT: Supported by National Science Center (Poland) grant 2015/17/N/HS6/03020.
BACKGROUND AND AIMS: Attention Deficit/Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders affecting approximately 5% of children and teenagers population. ADHD is characterized by developmentally inappropriate levels of inattention, impulsivity and overactivity. The aim of this study was to investigate attentional processes and their electrophysiological correlates in children and teenagers with ADHD diagnosis. METHODS: Fifty ADHD children and teenagers and 50 age-, and sex-matched healthy controls participated in this study. Participants performed Attention Network Test (ANT, Fan et al. 2002) – paradigm combining cue detection (Posner 1980) with flanker-type paradigm (Eriksen and Eriksen 1974). ANT allows for the behavioral assessment of different attention functions – alerting, orienting, and executive functions. During task performance EEG data were collected using 64 channel EGI Geodesic System. Measures of attention evaluated in attentional test were analyzed in terms of relation to EEG recording results. RESULTS: The results obtained on behavioral level revealed significant differences in ANT performance in above mentioned groups. ADHD participants, when compared with healthy controls, were less accurate and had longer reaction times in the condition evaluating executive attention. We have also found different patterns of Event Related Potentials (ERPs) related to ANT performance in these groups. Results of ERPs calculated for parietal electrodes cluster revealed that P300 amplitude was lower in ADHD group in comparison with controls. CONCLUSIONS: The results of EEG recordings suggest worse allocation of attention resources which may result in deficits in behavioral performance, especially in executive function of attention. These results are discussed in context of current views and theories on attentional networks and deficits observed in ADHD patients. National Science Centre Grant 2011/01/D/NZ4/04958.
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