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1

XII Małopolska Giełda Agroturystyczna w Krakowie

100%
Liberek A.
Wieś i Doradztwo. Pismo Małopolskiego Stowarzyszenia Doradztwa Rolniczego
|
2009
|
nr 2
2

Plasma protein and enzyme antioxidants in children with chronic hepatitis (CHH)

45%
Popadiuk S., Liberek A., Renke J., Szlagatys A., Wozniak M.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr Supplement 1
3

Diagnosis and treatment difficulties in 18-year-old male patient with hereditary hemochromatosis, chronic hepatitis B, Gilbert syndrome and ulcerative colitis

39%
Sikorska K., Liberek A., Romanowski T., Szlagatys-Sidorkiewicz A., Landowski P., Bielawski K. P.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 2
Among possible causes of chronic hepatitis in adolescents most common are infections, autoimmune disorders and metabolic diseases. Thus, diagnostic procedures should be multidirectional. This study reports diagnosis and treatment difficulties in an 18-year-old male patient with hereditary hemochromatosis (HH), ulcerative colitis (UC), chronic hepatitis B (CHB) and Gilbert syndrome. The presented case illustrates problems in diagnostics related to the presence of numerous disease conditions in one patient. It should be taken into consideration that these diseases coexisting in one patient can mutually affect their symptoms creating specific diagnostic difficulties.
4

Fecal lactoferrin, a marker of intestinal inflammation in children with inflammatory bowel disease

39%
Borkowska A., Liberek A., Luczak G., Jankowska A., Plata-Nazar K., Korzon M., Kaminska B.
Acta Biochimica Polonica
|
2015
|
tom 62
|
nr 3
5

Coexistence of type 1 diabetes mellitus and spinal muscular atrophy in an 8-year-old girl:a case report

39%
Borkowska A., Jankowska A., Szlagatys-Sidorkiewicz A., Sztangierska B., Liberek A., Plata-Nazar K., Kaminska B.
Acta Biochimica Polonica
|
2015
|
tom 62
|
nr 1
6

Evaluation of clinical usefulness of serum neopterin determination in children with bacterial infections

39%
Plata-Nazar K., Luczak G., Liberek A., Dudzinska-Gehrmann J., Sznurkowska K., Landowski P., Kaminska B.
Acta Biochimica Polonica
|
2015
|
tom 62
|
nr 1
7

Serum chemerin level, cytokine profile and nutritional status in children with cystic fibrosis

39%
Sznurkowska K., Kazmierska K., Sledzinski T., Zagierski M., Liberek A., Szlagatys-Sidorkiewicz A.
Acta Biochimica Polonica
|
2019
|
tom 66
|
nr 4
8

The role of Cag A positive Helicobacter pylori strains in gastritis in children

39%
Sikorska-Wisniewska G., Korzon M., Roszkiewicz A., Kur J., Banach P., Liberek A.
Journal of Physiology and Pharmacology. Supplement
|
1997
|
tom 48
|
nr 1
9

Graves' disease, celiac disease and liver function abnormalities in a patient - clinical manifestation and diagnostic difficulties

33%
Gora-Gebka M., Wozniak M., Cielecka-Kuszyk J., Korpal-Szczyrska M., Sznurkowska K., Zagierski M., Jankowska I., Plata-Nazar K., Kaminska B., Liberek A.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 2
 Autoimmune diseases due to probable common pathogenesis tend to coexist in some patients. Complex clinical presentation with diverse timing of particular symptoms and sophisticated treatment with numerous side effects, may cause diagnostic difficulties, especially in children. The paper presents diagnostic difficulties and pitfalls in a child with Graves' disease, celiac disease and liver function abnormalities.
10

Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children

33%
Kotlowska-Kmiec A., Bakowska A., Szarszewski A., Kaminska B., Luczak G., Radys W., Landowski P., Brodzicki J., Korzon M., Liberek A.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 3
433-438
The pathomechanism of Helicobacter pylori action upon gastric mucosa and its role in the pathogenesis of gastritis have not been fully elucidated. The aim of this study was to evaluate the most prevalent lymphocyte subpopulations of the gastric mucosa in gastritis in children, as well as to evaluate the expression of Fas and Fas ligand receptors (FasL), periapoptotic markers of gastric mucosa lymphocytes before and after H. pylori eradication. Forty nine patients aged 6 to 17 years, investigated due to chronic abdominal pain, were studied. The obtained tissue samples were analysed by immunohistochemistry. Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNγ) and Fas and FasL proteins in the gastric mucosa. B and T helper lymphocytes were found to play a major role in the inflammatory infiltration in the gastric mucosa in children during H. pylori infection. Their expression was found to decrease after eradication. The enhanced expression of Fas receptor on lymphocytes before treatment and a decrease of this expression after eradication of H. pylori were shown. It was demonstrated that there is a correlation between CD4 and Fas receptor expression that may induce apoptosis of the helper lymphocytes in infected children.
11

TGF-beta1, IL-10 and IL-4 in colostrum of allergic and nonallergic mothers

33%
Marek A., Zagierski M., Liberek A., Aleksandrowicz E., Korzon M., Krzykowski G., Kaminska B., Szlagatys-Sidorkiewicz A.
Acta Biochimica Polonica
|
2009
|
tom 56
|
nr 3
411-414
Objective: To determine transforming growth factor (TGF) β1, interleukin (IL) 4, and IL-10 concentrations in human milk and to assess the relationship between allergic disorders in mothers and the content of the interleukins in their milk. Material and methods: Thirty allergic and 46 healthy mothers were included in the study. Colostrum was collected 2-3 days after delivery. Cytokine concentrations were determined with commercial enzyme-linked immunosorbent systems. Results: TGF-β1was found in milk from 23 women in the control group (53.49%) and 11 in the allergy group (37.93%). When TGF-β1 was present, the median concentration was higher in the allergy group than in the control (61.5 and 30.4 pg/mL, respectively; P < 0.004). IL-10 was present in the colostrum of all the women and the median IL-10 concentration did not differ between the allergy (50.5 pg/mL) and control (51.5 pg/mL) groups. The probability of occurrence of a positive IL-4 value in the allergy group was greater than in the control group (chi-squared [df = 1] = 2.60, P < 0.053). Median IL-4 level did not differ significantly between the two groups (0.5 and 0.5 pg/mL respectively). Conclusions: TGF-β1 was detected less often in the colostrum of allergic mothers than in that of mothers without allergy (but the difference was not statistically significant). IL-4 was found more often in the colostrum of allergic mothers than nonallergic ones. The allergy status did not correlate with IL-10 concentration.
12

Peripheral regulatory T cells and anti-inflammatory cytokines in children with juvenile idiopathic arthritis

33%
Sznurkowska K., Bockowska M., Zielinski M., Plata-Nazar K., Trzonkowski P., Liberek A., Kaminska B., Szlagatys-Sidorkiewicz A.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr 1
13

Clinical parameters of inflammatory bowel disease in children do not correlate with four common polymorphisms of the transforming growth factor beta1 gene

27%
Liberek A., Jakobkiewicz-Banecka J., Kloska A., Swiderska J., Kmiec Z., Luczak G., Wierzbicki P., Liberek T., Marek K., Plata-Nazar K., Sikorska-Wisniewska G., Kaminska B., Wegrzyn G.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 4
Transforming growth factor β1 (TGF-β1) is a cytokine affecting cell proliferation and development, which also has an immunomodulatory activity. Correlations between polymorphisms of the TGF-β1 gene and clinical parameters of inflammatory bowel disease (IBD) were reported previously in adults. Here, we tested whether such correlations occur in pediatric patients suffering from IBD. One hundred and four pediatric IBD patients were involved in this study. Among them, 36 were diagnosed with Crohn's Disease (CD) and 68 were diagnosed with ulcerative colitis (UC). The control group consisted of 103 children, in which IBD was excluded. TGF-β1 levels were determined in plasma and intestinal mucosa samples. The presence of the TGF β1 protein and the amount of TGF β1 mRNA were estimated in intestinal mucosa by immunohistochemistry and reverse transcription Real-Time PCR, respectively. Four common polymorphisms of the TGF-β1 gene were investigated: -800G/A, -509C/T, 869T/C and 915G/C. No significant correlation between TGF-β1 genotypes and (i) TGF-β1 levels in plasma and tissue samples, (ii) TGF-β1 gene expression efficiency in intestinal mucosa, (iii) IBD clinical parameters and (iv) inflammatory activity could be detected in children suffering from IBD. We conclude that, contrary to previous suggestions, the four common polymorphisms of the TGF-β1 gene do not influence the susceptibility to or clinical parameters of IBD in the tested population of children.
14

Association between uridin diphosphate glucuronosylotransferase 1A1 (UGT1A1) gene polymorphism and neonatal hyperbilirubinemia

27%
Mazur-Kominek M., Romanowski T., Bielawski K., Kielbratowska B., Preis K., Domzalska-Popadiuk I., Slominska-Fraczek M., Sznurkowska K., Renke J., Plata-Nazar K., Sledzinska K., Sikorska-Wisniewska G., Gora-Gebka M., Liberek A.
Acta Biochimica Polonica
|
2017
|
tom 64
|
nr 2
15

Transforming growth factor beta1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts

27%
Liberek A., Kmiec Z., Wierzbicki P. M., Jakobkiewicz-Banecka J., Liberek T., Luczak G., Plata-Nazar K., Slominska-Fraczek M., Kaszubowska L., Gabik-Ciminska M., Wegrzyn A.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 4
Previously published studies on levels of the transforming growth factor-β1 (TGF-β1) protein and mRNA of the corresponding gene in patients suffering from inflammatory bowel diseases (IBD) gave varying results, leading to contradictory conclusions. To solve the contradictions, we aimed to assess longitudinally TGF-β1 protein and mRNA levels at different stages of the disease in children suffering from IBD. The study group consisted of 19 pediatric patients with IBD at the age between 3.5 and 18.4 years. The control group consisted of 42 children aged between 2.0 and 18.0 years. The plasma TGF-β1 concentration was measured with ELISA. mRNA levels of the TGF-β1 gene isolated from samples of the intestinal tissue were assessed by reverse transcription and real-time PCR. Levels of TGF-β1 protein in plasma and corresponding mRNA in intestinal tissue were significantly higher in IBD patients than in controls. TGF-β1 and corresponding transcripts were also more abundant in plasma and intestinal tissue, respectively, in patients at the active stage of the disease than during remission. In every single IBD patient, plasma TGF-β1 level and mRNA level in intestinal tissue was higher at the active stage of the disease than during remission. Levels of TGF-β1 and corresponding mRNA are elevated during the active stage of IBD but not during the remission. Longitudinal assessment of this cytokine in a single patient may help to monitor the clinical course of IBD.
16

Immune response against HtrA proteases in children with cutaneous mastocytosis

27%
Renke J., Kedzierska-Mieszkowska S., Lange M., Niedoszytko B., Liberek A., Plata-Nazar K., Renke M., Wenta T., Zurawa-Janicka D., Skorko-Glonek J., Lipinska B.
Acta Biochimica Polonica
|
2018
|
tom 65
|
nr 3
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