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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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The expression of mitochondrial, cytoplasmic and extracellular superoxide dismutase in the colonic wall of pigs suffering from swine dysenteria

100%
Chmielewska M., Losiewicz K., Podlasz P., Wasowicz K.
Polish Journal of Veterinary Sciences
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2013
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tom 16
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nr 3
The expression of 3 types of peroxide dismutase (SOD1, SOD2 and SOD3) was studied with Real-Time PCR in the colonic wall of domestic pig suffering from swine dysentery. The expression of enzymes was studied separately in the mucosa and the muscular membrane. It was found that in the mucosa the expression of SOD1 (cytoplasmic) did not change, while the levels of expression of mitochondrial SOD2 and extracellular SOD3 were raised in inflamed colon. More dramatic changes were seen in the muscular mebrane where expression of SOD1 rose twice, this of SOD2 rose ca. 5-fold and the expression of SOD3 rose dramatically, even 30-fold.The obtained data are contradictory to findings in other types of colonic inflammation, which were studied either in the whole colonic wall, or in mucosa alone. The results show a very strong reaction of antioxidant systems in the muscular membrane in the enteritis.
2
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The case of a massive Syphacia obvelata invasion in laboratory rats: diagnosis, treatment and prevention

100%
Michalski M., Chmielewska-Krzesinska M., Jakimiuk A., Losiewicz K.
Annals of Parasitology
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2016
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tom 62
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nr Suppl.
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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The application of circulating tumor cells detecting methods in veterinary oncology

88%
Chmielewska M., Losiewicz K., Socha P., Mecik-Kronenberg T., Wasowicz K.
Polish Journal of Veterinary Sciences
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2013
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tom 16
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nr 1
Cancers are one of the most common diseases affecting dogs. Many of them develop spontaneously and their biology and histopathology shows many similarities to human cancers. What more, it is proved that there are much more analogies in molecular mechanisms of cancer development between these two species. Human oncology is seeking more and more efficient methods for an early disease detection which results directly in the extended life expectancy of patients affected. One of the most modern trends in the diagnosis of cancer is to detect circulating tumor cells (CTC) in the blood of patients. It is known that these cells are responsible for the formation of metastases in distant organs what results in the patient death. Moreover, it’s confirmed that CTC are already present in patients’ bloodstream in the early stages of tumor development. There is no doubt that mechanism of metastasis development in dogs is identical and thus the CTC are also present in their bloodstream. Despite the intense researches there is still no optimal method of isolating cancer cells from the blood where they occur extremely rarely. The purpose of this study is to analyze the implications of the detection methods of tumor cells in the blood in veterinary oncology.
4

MiRNA-21, miRNA-10b, and miRNA-34a expression in canine mammary gland neoplasms

88%
Losiewicz K., Chmielewska-Krzesinska M., Socha P., Jakimiuk A., Wasowicz K.
Bulletin of the Veterinary Institute in Puławy
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2014
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tom 58
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nr 3
The expression of miRNA-21, miRNA-l0b, and miRNA-34a in malignant and benign tumours and non-neoplastic lesions in canine mammary gland, using real-time PCR with TaqMan probes was determined. The expression in normal tissues was compared to neoplastic and non-neoplastic lesions using one-way ANOVA test. Significant changes in miRNA expression in neoplastic tissues, as compared to normal ones, were demonstrated. In all neoplastic tissues, the miRNA-21 expression increased while in non-neoplastic lesions slightly decreased in comparison to normal ones. MiRNA-l0b expression in malignant and benign tumours increased in comparison to normal tissues and non-neoplastic lesions. MiRNA-34a expression profile in neoplastic and non-neoplastic tissues differed from other examined miRNAs (miRNA-21 and miRNA-l0b). In all samples miRNA-34a expression level decreased in comparison to normal tissues.
5

Changes in the expression of galanin and galanin receptors in the wall of the colon in pigs experimentally infected with Brachyspira hyodysenteriae

64%
Wasowicz K., Podlasz P., Chmielewska M., Losiewicz K., Kaleczyc J., Zmudzki J., Zalecki M., Pidsudko Z., Lakomy M.
Bulletin of the Veterinary Institute in Puławy
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2014
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tom 58
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nr 1
The expression of galanin (GAL) and its three receptors (GalR1, GalR2, and GalR3) were studied with real-time PCR in the colonic wall of pigs suffering from experimental colitis caused by the infection with Brachyspira hyodysenteriae. The expression was studied in the muscular membrane, mucosa/submucosa layer, and in lymphocytes isolated from mucosa/submucosa. The expression levels were normalized to glyceraldehyde-6-phosphate dehydrogenase (GAPDH) expression and compared to expression levels in control animals. GAL expression was found in all three studied compartments of the colonic wall. A significant decrease in GAL expression level was found in the mucosa/submucosa and in isolated lymphocytes, whereas the decrease was much less profound in the muscular membrane. In the case of galanin receptors their expression was found in all studied compartments of the colonic wall, however at different levels, as compared to GAPDH expression. The decrease of galanin receptors expression was found in all studied compartments of the colonic wall of the sick animals.
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