Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 9

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Wpływ stężenia sodu w płynie dializacyjnym na aktywność dopamino-beta-hydroksylazy u pacjentów hemodializowanych

100%
Solski J., Ksiazek A., Spasiewicz D.
Diagnostyka Laboratoryjna
|
1986
|
tom 22
|
nr 2-3
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Wpływ zawartości sodu w dializacie na poziom amin katecholowych, aldosteronu i aktywność reninową osocza w okresie międzydializacyjnym u pacjentów hemodializowanych

100%
Solski J., Ksiazek A., Wawrzycki S.
Diagnostyka Laboratoryjna
|
1986
|
tom 22
|
nr 6
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Własna modyfikacja radioenzymatycznej metody oznaczania amin katecholowych

100%
Solski J., Jusiak J., Ksiazek A.
Diagnostyka Laboratoryjna
|
1984
|
tom 20
|
nr 4
4

Kinetic properties of leak channel currents in medial prefrontal cortex (mPFC) pyramidal neurons in rats

100%
Ksiazek A., Witkowski G., Szulczyk P.
Acta Neurobiologiae Experimentalis
|
2011
|
tom 71
|
nr S
The prefrontal cortex is involved in cognitive function. It has been suggested that dysfunction of mPFC occurs in widespread neuropsychiatric disorders. The purpose of this study was to classify K+ channel currents along their kinetic properties in mPFC pyramidal neurons. Channel current recordings were performed from dispersed pyramidal neurons in cell-attached configuration in symmetrical K+ solutions. The kinetic properties of 100 channel currents were analysed. A total of 27% resembled leak, TREKlike channel currents. Their mean amplitude was 6.9 pA, dwell time was 1.31 ms, and NPo was 0.009 at -50 mV. Their outward and inward conductances were 160 and 150 pS, respectively. The channel currents were strongly mechanosensitive. A total of 27% resembled TASK-like channel currents. Their mean amplitude was 2.0 pA, dwell time was 0.58 ms and NPo 0.11 at -50 mV. Inward and outward conductances were 48 and 71 pS, respectively. A total of 34% were BK-like channel currents. Their amplitude was 5.8 pA, dwell time was 1.1 ms, and NPo was 0.03 at +25 mV. Their outward conductance was 177 pS. In cell-attached configuration, the BK channel currents were only outward. The application of Ca2+ ions from the intracellular side in inside-out configuration strongly activated these channels. A total of 5% channel currents were not classified. Surprisingly, we did not find voltage dependent K+ channel currents. We concluded that the leak-type channel currents could be important players in setting the level of membrane potential in mPFC pyramidal neurons.
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Poziom tyreotropiny, tyroksyny, trójjodotyroniny w osoczu pacjentów hemodializowanych płynem wysokosodowym i niskosodowym

100%
Solski J., Ksiazek A., Tarkowska A., Jankowska H.
Diagnostyka Laboratoryjna
|
1988
|
tom 24
|
nr 1
6

Effect of dopamine receptor stimulation on voltage-dependent fast-inactivating Na plus currents in medial prefrontal cortex (mPFC) pyramidal neurons in adult rats

100%
Szulczyk B., Ksiazek A., Ladno W., Szulczyk P.
Acta Neurobiologiae Experimentalis
|
2012
|
tom 72
|
nr 4
Impaired working memory is a common feature of neuropsychiatry disorders. It is dependent on control of the medial prefrontal cortex (mPFC) neurons by dopamine. The purpose of this study was to test the effects of a D1/5-type dopamine receptor agonist (SKF 38393, 10 ^M) on the membrane potential and on voltage-dependent fast-inactivating Na+ currents in mPFC pyramidal neurons obtained from adult (9-week-old) rats. Treatment of the pyramidal neurons with SKF 38393 did not affect the membrane potential recorded with the perforated-patch method. When recordings were performed in cell- attached configuration, the application of SKF 38393 did not change the Na+ current amplitude and shifted the current- voltage relationship of the Na+ currents towards hyperpolarisation, thus resulting in an increase of the current amplitudes in response to suprathreshold depolarisations. Pretreatment of the cells with a D1/5 receptor antagonist (SCH 23390, 10 ^M) abolished the effect of the D1/5-type receptors on Na+ currents. The effect of the D1/5 agonist was replicated by treating the cells with a membrane-permeable analogue, cAMP (8-bromo-cAMP, 100 ^M), and the effect was blocked by treating the cells with a protein kinase A inhibitor, (H-89, 2 ^M). In recordings performed from mechanically and enzymatically dispersed pyramidal neurons in the whole-cell configuration, when the cell interior was dialysed with pipette solution, application of the D1/5 agonist decreased the Na+ current amplitude without changing the current-voltage relationship. We conclude that in the mPFC pyramidal neurons in slices with an intact intracellular environment (recordings in the cell-attached configuration), the activation of D1/5 dopamine receptors increases the fast-inactivating Na+ current availability in response to suprathreshold depolarisations. The maximum Na+ current amplitude was not changed. A cAMP/protein kinase A pathway was responsible for the signal transduction from the D1/5 dopamine receptors to the Na+ channels.
7

Properties of single noninactivating K plus channel currents in medial prefrontal cortex (mPFC) pyramidal neurons

100%
Ksiazek A., Ladno V., Witkowski G., Szulczyk P.
Acta Neurobiologiae Experimentalis
|
2012
|
tom 72
|
nr 2
Distorted activity of mPFC neurons occurs in age-dependent, widespread neuropsychiatric disorders. Single noninactivating K+ channel currents were recorded in cell attached configuration from freshly dispersed mPFC pyramidal neurons. Neurons were obtained from young (20 days old, 185 channels analyzed), periadolescent (40 days old, 71 channels analyzed) and adult rats (60 days old, 84 channels analyzed). There were found 3 major groups of channel currentsin tested neurons: (1) Ca++ dependent K+ channel currents; these channel currents when recorded in cell attached configuration expressed only outward conductance (150 pS); in inside out configuration they expressed also inward conductance when Ca++ ions applied to the cytoplasmatic side of the membrane; (2) large conductance leak channel currents showed outward (150 pS) and inward (150 pS) conductance in cell attached configuration; these channels were strongly mechanosensitive; (3) small conductance leak channel currents had outward and inward conductance about 30–40 pS. Each category of tested channel currents had similar properties biophysical properties in neurons obtained from rats of different age. Smaller proportion of Ca++ dependent K+ channel currents and larger proportion large conductance leak channel currents were found in pyramidal neurons obtained from preadolescent rats comparing to young and adult rats (see table). Supported by NN401584638 and NN401076537.
8
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Wykorzystanie produktów pochodzenia zwierzęcego i roślinnego w diecie osób z ostrym uszkodzeniem nerek

100%
Grzebalska A. M., Babicz M., Ksiazek A.
Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica
|
2017
|
tom 35
|
nr 1
9

Soluble and membrane bound IL-2 receptors [ alpha and beta chains ] in chronic hemodialyzed patients

76%
Koziol-Montewka M., Rolinski J., Ksiazek A., Baczek A., Brzozowski W., Spasiewicz D.
Folia Histochemica et Cytobiologica
|
1997
|
tom 35
|
nr 2
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.