ASC/Icg (Antidepressant Sensitive Catalepsy) mouse strain selected for high predisposition to pinch-induced catalepsy is characterized by depressive-like behavior and impaired immune response. Chronic treatment with SSRI fl uoxetine attenuated catalepsy manifestation and normalized a decreased number of rosette-forming cells (RFC) in spleen in ASC mice. Chronic fl uoxetine administration had no effect on catalepsy and RFC number in mice of parental cataleptic CBA/Lac strain. Fluoxetine failed to alter 5-HT1A receptor functional activity in mice of both strains and diminished 5-HT2A receptor functional activity in CBA but not in ASC mice. No effect on cortical 5-HT1A and 5-HT2A receptor mRNA levels and on 5-HT1A receptor, tph2 (tryptophan hydroxylase-2) and SERT (serotonin transporter) mesencephalic gene expression was observed in ASC mice. The data evidenced the validity of ASC mouse strain as prospective model for research of psychoneuroimmune mechanisms of antidepressant effects and development of depressive-like state.
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