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The neuronal basis of false recognition is still a subject of extensive debate. We used voxel based morphometry (VBM) to examine structural brain correlates of false and correct recognition processes. Since several studies indicate that emotional content facilitates false recognition we employed emotional stimuli taken from International Affective Picture System (IAPS). Behavioral measures, i.e., true and false recognition rates were used as covariants in VBM analyses. VBM results indicated that the true recognition correlated positively with grey-matter (GM) density in bilateral amygdala, anterior cingulate and middle temporal gyrus, i.e., brain regions, involved in the memory of emotional material, as revealed by fMRI results. False recognition correlated negatively with GM density in prefrontal areas (BA47 and BA9), which were implicated in false recognition by our previous fMRI study. Taken together, these results support the role of the prefrontal cortex in monitoring retrieval and limiting the probability of false recognition. Our VBM fi ndings (1) point to the brain structures critical for correct and false recognition of emotional stimuli and (2) disclose structural differences between these processes.
The study was aimed at testing whether the repetition priming was influenced by affective valence of visual stimuli. Neutral and emotionally negative words and images were shown in the right or in the left visual field. Each of the stimuli was repeated twice, with 2 to 4 other stimuli presented between repetitions. The subjects' task was detection of a stimulus. Responses were given by index finger of the left or right hand. The task was the same for all stimuli, the new and the repeated ones. Reaction times were measured and analyzed. The effects of repetition priming were significant only for neutral stimuli: repeated items were detected faster than the new ones. For emotionally negative items, generally no priming was observed. Interestingly, new emotionally negative stimuli were detected significantly faster in comparison to neutral stimuli. The results are discussed in relation to attentional processes involved in processing of affective stimuli.
Zastosowanie technologii powlekania żywności proszkami daje producentom możliwość stworzenia szerokiej gamy produktów o różnorodnych smakach i kolorach. Standardowym przykładem wykorzystania tej techniki są przekąski z nanoszoną solą lub różnego rodzaju mieszankami przypraw oraz składnikami funkcjonalnymi. W artykule przedstawiono urządzenia technologiczne wykorzystywane w operacji powlekania, takie jak bębny powlekające i przenośniki taśmowe, z uwzględnieniem systemów dozowania proszków. Scharakteryzowano technikę powlekania elektrostatycznego, która wykazuje lepszą wydajność w porównaniu z metodą konwencjonalną. Zwrócono uwagę na właściwości proszków - rozmiar, kształt, sypkość, gęstość i rozpuszczalność - wpływające na skuteczność procesu. Nakreślono problemy występujące podczas powlekania, jak: niewystarczająca adhezja, pylenie, kohezyjność, zapychanie i wzbieranie, oraz zaproponowano sposoby ich rozwiązania
Event-related potentials were used to examine if the brain response (N400 component) in dyslexic children is modulated by phonological or semantic priming, similarly to age-matched controls. ERPs were recorded while the children listened to word lists in which the semantic and phonological congruency of the terminal words were manipulated. Dyslexics exhibited a dissociation of priming effects depending on whether semantically or phonologically loaded primes were used. An enhancement of N400 amplitude to semantically incongruent words was observed, although this effect was reduced and delayed compared to that seen in controls. Direct comparison of the performance of the two groups in the semantic priming task revealed that they differed only in their response to semantically incongruent words. In the phonological priming task, rather than an enhancement of the N400 amplitude found in controls, dyslexics displayed a reduction of the N400 to the incongruent condition in comparison to the congruent condition. In this task, the studied groups differed in both the phonologically congruent and incongruent conditions. These results suggest that when faced with phonological priming, dyslexics have problems with both matching for similarities (integration into context) and incongruency detection. In the case of semantic priming, the integration of semantic context seems relatively intact in dyslexics, but they experience diffi culties in detecting the shift from one semantic category to another.
The aim of our study was to check whether maternal presence during the post-weaning period affects the onset of hibernation and weight gain under unlimited food supply in juvenile edible dormice Glis glis. We investigated four groups of siblings growing up in the presence of the mother (“with mother”; n=17) and three groups of juveniles separated from the mother after weaning (“without mother”, n = 17). We found that: (i) more juveniles started hibernation from the group “without mother” than from the group “with mother” (χ² = 8.24, P < 0.01) at the end of study, when most dams entered hibernation, (ii) weight was not a factor which determined the decision of entering hibernation (iii) juveniles growing up “without mother” did not differ significantly from juveniles raised “with mother” in terms of mean body mass during the last weighing before hibernation (t = 0.48, P = 0.63) and maximum body mass (t = 0.11, P = 0.91), (iv) the presence of the mother may influence the process of making decisions by juveniles about terminating activity and entering hibernation.
Purpose. The aim of the study was to assess the in vitro potency of pentoxifylline (PTX) and one of its most active metabolites lisofylline (LSF) to improve rheological properties of red blood cells (RBC) from healthy individuals and patients with chronic venous disease (CVD). Additionally, the study aimed to compare the effects of PTX and LSF on RBC deformability and aggregation. Methods. Blood samples were collected from healthy volunteers (antecubital vein) and from CVD patients (varicose and antecubital vein). Deformability and aggregation of RBC were assessed using Laser-assisted Optical Rotational Cell Analyser (LORCA). Results. PTX and LSF increased RBC elongation significantly. Additionally, RBC incubation with PTX resulted in a marked decrease in RBC aggregation. PTX reduced the tendency towards the formation of RBC aggregates and of their stability. The beneficial effect of PTX on RBC aggregation was most apparent for those cells whose aggregation tendency and aggregate stability was the greatest. Conclusions. In vitro addition of PTX or LSF effectively increased deformability of RBC from healthy donors and patients with CVD. Thus, LSF may contribute to the in vivo hemorheological effects of pentoxifylline. On the other hand, there was no significant effect of LSF on aggregation of RBC in vitro. Hence, LSF has no contribution to this particular effect of PTX. Additionally, the present study demonstrated the use of RBC with impaired deformability and aggregation for the evaluation of in vitro rheological activity of xenobiotics.
INTRODUCTION: Surprise (i.e., errors in outcome prediction) drives reinforcement learning. Animal studies point to the critical role of the centromedial subdivision (CMA) of the amygdala in signaling reinforcement-related surprise. Little is known as to the role of the CMA in this process in humans, as the problem of functional organization of the human amygdala was undertaken by only few studies. AIM(S): The goal of this study was to investigate the role of the human amygdala subdivisions in signalling surprise during reinforcement learning. METHOD(S): We used a Pavlovian conditioning task. The task was composed of two trial types: aversive and neutral, in which small amounts of aversive (0.4 M NaCl) and neutral (25 mM KCl and 2.5 mM NaHCO3) gustatory stimuli (liquids) were provided to participants. In the beginning of each trial, participants were presented with two visual cues: one associated with a high probability (on 70% of occasions) and the other with a low probability (on 30% of occasions) of obtaining gustatory stimulus. After a few seconds, one of visual cues disappeared and the subjects’ task was to indicate whether the remaining cue forerun liquid delivery. In an fMRI study, we compared the amygdala activity during: 1) reinforcement-related surprise (unexpected vs. expected delivery of aversive stimuli), and 2) surprise not related with the reinforcement (unexpected vs. expected delivery of neutral stimuli). RESULTS: We found the right CMA activation during reinforcement-related surprise, whereas surprise not related with the reinforcement did not activate any amygdala subdivision. CONCLUSIONS: The results showed selective involvement of the CMA in signalling reinforcement-related surprise in humans. Moreover, they prove that investigation of the amygdala at the level of distinct subdivisions using fMRI in humans should be valuable direction for future studies. This work was supported by a grant from the Polish National Science Centre based on decision number DEC-2014/15/B/HS6/03658. FINANCIAL SUPPORT: Polish National Science Centre grant No. DEC-2014/15/B/HS6/03658.
The ability to “read” the information about facial identity, expressed emotions, and intentions is crucial for non-verbal social interaction. Neuroimaging and clinical studies consequently link face perception with fusiform gyrus (FG) and occipital face area (OFA) activity. Here we investigated face processing in an adult, patient PK, diagnosed with both high functioning autism spectrum disorder (ASD) and developmental prosopagnosia (DP). Both disorders have a significant impact on face perception and recognition, thus creating a unique neurodevelopmental condition. We used eye-tracking and functional magnetic resonance imaging (fMRI) method. Eye-tracking and fMRI results of PK were compared to results of control subjects. Patient PK showed atypical gaze-fixation strategy during face perception and typical patterns of brain activations in the FG and OFA. However, a significant difference between PK and control subjects was found in the left anterior superior temporal sulcus/middle temporal gyrus (aSTS/MTG). In PK the left aSTS/MTG was hypo-activated in comparison to the control subjects. Additionally, functional connectivity analysis revealed decreased inter-hemispheric connectivity between right and left aSTS/MTG in ‘ASD and DP’ patient during face recognition performance as compared to the control subjects. The lack of activity in the left aSTS/MTG observed in the case of the clinical subject, combined with the behavioral, eye-tracking, and neuropsychological results, suggests that impairment of the cognitive mechanism of face recognition involves higher level of processing. It seems to be related to insufficient access to semantic knowledge about the person when prompted by face stimuli.
Previous imaging studies have identified many brain regions activated during reasoning, but there are differences among the findings concerning specific regions engaged in reasoning and the contribution of language areas. Also, little is known about the relation between task complexity and neural activation during reasoning. The present fMRI study investigated brain activity during complex four-term transitive reasoning with abstract material (determinate or partially indeterminate) and compared the resulting images to those obtained during a memorization task. The memory condition required subjects to memorize unrelated elements whereas the reasoning conditions required them to integrate information from premises and to infer relations between elements. After contrasting the two kinds of reasoning conditions with the memory condition we found that right prefrontal and bilateral parietal regions are specifically activated during reasoning. We also demonstrated that different reasoning requirements - the possibility of constructing one (determined reasoning) versus several (undetermined reasoning) models of a situation during task solving - lead to different patterns of brain activity, with higher prefrontal (PFC) activity accompanying undetermined reasoning. We interpret the PFC activity as a reflection of simultaneous maintenance and manipulation of information in reasoning. These findings provide new evidence that specific forms of reasoning (abstract and undetermined) demand recruitment of right PFC and hemispheric coordination and lend new support to the mental model theory of relational reasoning.
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