Molecular and behavioral patterns associated to stress responsivity and PTSD risk

• Autorzy: Szklarczyk K. , Smutek M. , Korostynski M. , Solecki W. , Golda S. , Przewlocki R.
• Języki publikacji: EN

Abstrakty

EN

Post-traumatic stress disorder (PTSD) is a chronic anxiety condition that develops as a result of a terrifying event. Clinical studies show that only about 10% of trauma-exposed people suffer from PTSD. Our research was focused on endophenotypes and molecular biomarkers of PTSD in an animal model. Differences in response to stress among inbred mouse strains (C57BL/6J, DBA/2J, SWR/J and 129P3/J) were compared: a single intense footshock was applied and ultrasonic vocalization during/after the stress was measured. Long-lasting effects were assessed 4-6 weeks after the traumatic event: conditioned and sensitized fear, social withdrawal, depressive-like behavior and susceptibility to drug addiction. SWR/J strain displayed the lowest conditioned fear, whereas sensitized fear was increased over time in C57BL/6J mice. Moreover, C57BL/6J strain exhibited increase in depressive-like behavior, while DBA/2J strain displayed increased social withdrawal. In addition, it was observed that exposition to traumatic stress increased sensitivity to rewarding properties of morphine in 129P3/J mice. Diverse long-lasting behavioral consequences of exposition to stress were associated with changes in basal and stress-induced profile of glucocorticoid receptor-dependent (GR) genes (e.g., Fkbp5 and Tsc22d3) in amygdala. Furthermore, our research showed that administration of GR antagonist disrupted reconsolidation of the traumatic event memory. Our research supports a model in which genetic factors are important for phenotypic variation in responsivity to stress. These genes may provide novel insight into mechanisms of stress-related disorders. This work was supported by Polish MSHE grants NN405 274137, N405 143238, IUVENTUS Plus and POIG De-Me-Ter 3.1

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: S
• Opis fizyczny: p.62

Twórcy

autor

Szklarczyk K.

• Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Krakow, Poland

autor

Smutek M.

• Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Krakow, Poland

autor

Korostynski M.

• Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Krakow, Poland

autor

Solecki W.

• Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Krakow, Poland

autor

Golda S.

• Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Krakow, Poland

autor

Przewlocki R.

• Department of Molecular Neuropharmacology, Institute of Pharmacology PAS, Krakow, Poland

Uwagi

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