Cytokine-mediated cross-talk between glia and neurons: neuropathological implications for epilepsy

• Autorzy: Vezzani A. , Balosso S. , Maroso M. , Rizzi M. , Noe F. , Zardoni D. , Frasca A. , Ravizza T.
• Języki publikacji: EN

Abstrakty

EN

Recent fi ndings in experimental models and in the clinical setting highlight the possibility that infl ammatory processes in the brain contribute to the etiopathogenesis of seizures and to the establishment of a chronic epileptic focus. Prototypical infl ammatory cytokines such as IL-1β and TNF-α are overexpressed in epileptogenic brain areas, prominently by glia and to a lesser extent by neurons and endothelial cells of the blood brain barrier. Cytokine receptors are also upregulated, and the related intracellular signalling is activated, highlighting both autocrine and paracrine actions of cytokines in diseased brain. Cytokines can profoundly affect neuronal network excitability, and the recent demonstration of molecular and functional interactions between cytokines and classical neurotransmitters, such as glutamate and GABA, provides one mechanism by which cytokines affect neuronal activity. These interactions may result in increased tissue excitability leading to seizures and cell loss. These fi ndings describe novel communications between glia and neurons which may contribute to pathological conditions (e.g. seizures, neurodegeneration) characterized by the activation of infl ammatory processes, thus highlighting potential new targets for therapeutic intervention.

Słowa kluczowe

EN

brain; etiopathogenesis; seizure; cytokine; glial cell; neuron; neuropathological implication; epilepsy; therapeutic intervention

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.274

Twórcy

autor

Vezzani A.

• Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy

autor

Balosso S.

• Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy

autor

Maroso M.

• Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy

autor

Rizzi M.

• Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy

autor

Noe F.

• Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy

autor

Zardoni D.

• Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy

autor

Frasca A.

• Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy

autor

Ravizza T.

• Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy