Colocalisation of glucocorticoid and 5-HT1A receptor immunoreakrivity-expressing cells in the brain structures of low and high anxiety rats

• Autorzy: Lebner M. , Taracha E. , Maciejak P. , Szyndler J. , Skorzewska A. , Turzynska D. , Sobolewska A. , Wiskowska-Stanek A. , Hamed A. , Bidzinski A. , Plaznik A.
• Języki publikacji: EN

Abstrakty

EN

In recent years we have elaborated an animal model to examine the neurochemical background of differences in the individual responses to conditioned aversive stimuli, using the strength of a rat contextual fear test, as a discriminating variable: low responders (LR), i.e. rats with duration of a freezing response one standard error, or more, below the mean value and high responders (HR), i.e. rats with duration of a freezing response one standard error, or more, above the mean value. It was found that 1.5 h after a testing session of contextual fear test, the LR animals showed a higher density of 5-HT1A and glucocorticoid immunoreactivity-expressing cells (GRsir) in the cortical M2 area and hippocampal dentate gyrus as well as an increased number co-expressing 5-HT1A /GRs-ir in the same areas. The HR rats had a signifi cantly higher concentration of 5-HT1A and GRs-ir in the basolateral amygdala. The present data add more arguments for the neurobiological background of differences in individual responses to aversive conditioned stimuli.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.369

Twórcy

autor

Lebner M.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Taracha E.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Maciejak P.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Szyndler J.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Skorzewska A.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Turzynska D.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Sobolewska A.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Wiskowska-Stanek A.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Hamed A.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Bidzinski A.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Plaznik A.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland