c-Fos 5HT and CRF immunostaining of the prefrontal cortex areas in the rats differing in the streigth of a fear response

• Autorzy: Wislowska-Stanek A. , Lehner M. , Taracha E. , Skorzewska A. , Maciejak P. , Szyndler J. , Plaznik A.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to examine the neurochemical background of differences in the individual responses to conditioned aversive stimuli, using the strength of a rat conditioned freezing response (the contextual fear test), as a discriminating variable. It was shown that high responder (HR), i.e. rats with duration of a freezing response one standard error, or more, above the mean value, had a higher c-Fos activity in the FrA and PrL prefrontal cortical areas, and stronger 5HT immunostaining in the FrA. However, these animals had lower CRF immunostaining in the same cortical areas in comparison with low responder (LR), i.e. rats with the duration of a freezing response one standard error, or more, below the mean value. The LR group vocalized more during test session in the aversive band, and had higher serum levels of corticosterone, examined 10 min after test session. It was shown that different natural patterns of responding to conditioned aversive stimuli are associated with different expression of CRF and serotonergic- innervation of prefrontal cortical areas.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.360-361

Twórcy

autor

Wislowska-Stanek A.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Lehner M.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Taracha E.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Skorzewska A.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Maciejak P.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland
• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Szyndler J.

• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland

autor

Plaznik A.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland
• Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland