Characteristic of alcohol-preferring WHP and non-preferring WLP lines of rats

• Autorzy: Dyr W. , Cwiek M. , Taracha E. , Kostowski W.
• Języki publikacji: EN

Abstrakty

EN

The selected lines of rats WHP (Warsaw High Preferring) and WLP (Warsaw Low Preferring) determine the animal model to investigate neurobiological mechanism of ethanol action. WHP rats drink excessive amounts of alcohol whereas WLP rats drink only small amounts. Patterns of ethanol consumption in WHP and WLP lines are constant. Due to cessation of alcohol intake the WHP rats have developed features of withdrawing signs. Level of dopamine and serotonine is lower in some brain regions of the WHP rats. WHP rats show an increased responsiveness to the stimulatory effects of low dose of ethanol.It has been suggested that acquisition of acute tolerance to ethanol may promote increased ethanol consumption. The effects of acute administration of ethanol (dose – 2.3 g/kg i.p.) were established by assessing ethanol-induced motor impairment, hypothermia and blood ethanol level in WHP and WLP rats. The rotarod model was used to measure motor impairment. Results have been revealed that WHP rats recovered motor activity and normal temperature when blood ethanol was at the highest level, indicating the development of acute tolerance to ethanol. The WLP rats showed similar recovery to WHP rats but at the lower blood ethanol level.Tolerance to ethanol may have a great value as a predictor of susceptibility to alcoholism therefore may signifi cant means in the relation to alcohol consumption and dependence. Generally tolerance is thought as the neuroadaptive processes to intoxicate effect of ethanol.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 3
• Opis fizyczny: p.349

Twórcy

autor

Dyr W.

• Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Cwiek M.

• Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Taracha E.

• Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland

autor

Kostowski W.

• Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland