To have or not to have a break. Neural connectivity patterns during task-to-rest transitions in healthy subjects and patients with obsessive-compulsive disorder (OCD)

• Autorzy: Zurowski B. , Kordon A. , Hohagen F. , Buetof S.J.
• Języki publikacji: EN

Abstrakty

EN

INTRODUCTION: The investigation of resting state connectivity typically provides a static view on neuronal integration that does not capture dynamic transitions between rest and task-related network connectivity underlying real life functioning – particularly in neuropsychiatric disorders characterized by cognitive inflexibility and difficulties to disengage from cognitive processing. AIM(S): The aim of the present study was to characterize network connectivity differences between OCD patients and healthy controls. Using fcMRI, we explored whether engagement in a perceptual decision task has differential impact on subsequent topographical and timely aspects of neural connectivity. METHOD(S): fMRI data from 18 OCD and 14 healthy subjects was obtained using a 3T Siemens scanner before (fixation1), during, and after (fixation2) a luminance‑based perceptual decision task. For analysis SPM8 and CONN Toolbox were used. To test for differences in spontaneous and task-induced fcMRI study groups were contrasted in fixation1 and the decision block, respectively. In a second analysis, fixation1 was compared to fixation2 to determine the impact of the decision task. In addition, the fixation2 period was segmented into three time windows which were then contrasted separately with fixation1 and with each other. RESULTS: Healthy controls had stronger connections between the orbitofrontal cortex and superior and medial frontal gyri during fixation1 and during the decision task. The segmentation of fixation 2 into 3 time windows revealed that only the 1. window differed significantly from fixation1 in controls. In contrast, the fcMRI discrepancy in OCD was significant across the entire period of fixation2. CONCLUSIONS: Healthy subjects and OCD patients show differences between pre‑task and post‑task resting state network connectivity, which is prolonged in OCD patients, however. The investigation of dynamic rather than static network connectivity is strongly encouraged both in healthy and neuropsychiatric populations. FINANCIAL SUPPORT: Medical Faculty of the University of Lübeck, Deutsche Forschungsgemeinschaft (DFG, Grant BR 1766/4), Federal Ministry of Education and Science (BMBF).

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2017
• Tom: 77
• Numer: Suppl.1
• Opis fizyczny: p.128

Twórcy

autor

Zurowski B.

• Center for Integrative Psychiatry, University of Luebeck, Germany

autor

Kordon A.

• Center for Integrative Psychiatry, University of Luebeck, Germany

autor

Hohagen F.

• Center for Integrative Psychiatry, University of Luebeck, Germany

autor

Buetof S.J.

• Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Germany