Effects of alfacalcidol on the contractile properties of the gastrocnemius medialis muscle in adult and old rats

• Autorzy: Testerink J. , Degens H. , Rittweger J. , Shiraishi A. , Jaspers R.T. , De Haan A.
• Języki publikacji: EN

Abstrakty

EN

Vitamin D deficiency is associated with muscle weakness. It is unknown, however, how supra-physiological levels of vitamin D affect skeletal muscle. To investigate the effects of increased serum vitamin D (1,25 (OH)2D3 or 1,25D) levels on the contractile properties of the medial gastrocnemius muscle, adult and old female Fischer344 x Brown Norway F1 rats were orally treated with vehicle or the vitamin D analogue alfacalcidol for 1 or 6 weeks. Alfacalcidol treatment resulted in elevated 1,25D serum levels. This was accompanied by hypercalcaemia and a reduction in body mass, the latter largely attributable to a reduced food intake. However, kidney function, as reflected by normal creatinine serum levels, as well as heart mass were unaffected. The 17% reduction in maximal isometric force and power was explicable by a similar loss of muscle mass. The force-frequency relationship of the 6-week-treated old rats was shifted to the left, but neither the shape of the force-velocity relationship nor the fatigability of the muscle were altered. Supra-physiological doses of vitamin D were accompanied by significant reductions in body and muscle mass, but not by an improvement in muscle functioning. Weight loss was largely due to a reduced food intake, while the left shift in the force-frequency relation may be due to increased 1,25D levels.

Słowa kluczowe

EN

alfacalcidol; body mass; creatinine; force; gastrocnemius muscle; hypercalcemia; kidney function; muscle contraction; muscle mass; muscle weakness; rat; skeletal muscle; vitamin D; weakness

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2011
• Tom: 62
• Numer: 1
• Opis fizyczny: p.111-118,fig.,ref.

Twórcy

autor

Testerink J.

• Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, U.K.

autor

Degens H.

autor

Rittweger J.

autor

Shiraishi A.

autor

Jaspers R.T.

autor

De Haan A.