The oxidative DNA damage analysis in coke oven workers

• Autorzy: Adamek B. , Kasperczyk J. , Wiczkowski A. , Steplewski Z. , Strzelczyk J. , Gawron K.
• Języki publikacji: EN

Abstrakty

EN

Polycyclic aromatic hydrocarbons (PAHs) are DNA adducts forming carcinogens. The DNA adducts, especially 8-oxoguanine (8-oxoG), are the established biomarker of environmental genotoxic compounds exposure. The aim of this study was to determine the 8-oxoG presence in peripheral blood lymphocytes of 27 coke oven workers and 21 rural area inhabitants comparison. The study and control groups were not significantly different according to %8-oxoG-positive lymphocytes. In the control group the difference between smokers and non-smokers was significant (p<0,01). %8-oxoG in non-smokers from the study and control groups were significantly different (p<0,009). The occupational exposure and smoking cigarettes are important oxidative DNA damage causing factors.

Słowa kluczowe

EN

polycyclic aromatic hydrocarbon; DNA adduct; carcinogen; 8-oxoguanine; genotoxic compound; exposure; blood lymphocyte; coke oven worker; occupational exposure; DNA damage; cigarette smoking

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2004
• Tom: 13
• Numer: Suppl.2, Part 1
• Opis fizyczny: p.29-31,ref.

Twórcy

autor

Adamek B.

• Department of General Biology, Silesian Medical University, Katowice, Poland

autor

Kasperczyk J.

autor

Wiczkowski A.

autor

Steplewski Z.

autor

Strzelczyk J.

autor

Gawron K.