Functional characterization of human Kindlin-2 core promoter identifies a key role of SP1 in Kindlin-2 transcriptional regulation

• Autorzy: Khan A. , Shimokawa T. , Stromblad S. , Zhang H.
• Języki publikacji: EN

Abstrakty

EN

Kindlin-2 is a recently identified FERM and PH domain containing integrin interacting protein. Kindlin-2 is ubiquitously expressed in normal tissues. So far, much effort has been spent exploring the functional aspects of Kindlin-2. However, the transcriptional regulation of Kindlin-2 has not yet been investigated. In this study we identified and functionally characterized the promoter of the human Kindlin-2 gene. We show that the core promoter of Kindlin-2 is a 39 base pair long GC rich fragment located −122/-83 upstream of the Kindlin-2 transcription start site. Functional characterization of this core promoter region by both in silico as well as in vitro/in vivo analysis shows that the transcription factor SP1 plays an important role in regulation of Kindlin-2 expression.

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2011
• Tom: 16
• Numer: 4
• Opis fizyczny: p.638-651,fig.,ref.

Twórcy

autor

Khan A.

• Department of Biosciences and Nutrition, Center for Biosciences, Karolinska Institutet, Novum, 141 83 Huddinge, Sweden

autor

Shimokawa T.

autor

Stromblad S.

autor

Zhang H.

Bibliografia

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