Disturbances of anti-oxidative balance in rats caused by aflatoxin B1

• Autorzy: Wojtowicz-Chomicz K. , Stadnik A. , Kowal M. , Sztanke K. , Sztanke M. , Borzecki A.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to analyse the effect of aflatoxin B₁ (AFB1) on total antioxidant status (TAS). The studies were conducted on Wistar male rats weighing 190-200 g. The animals were given for 7 d varied doses of AFB1, from 0.5 mg/kg b.w. to 2 mg/kg b.w. TAS and concentration of uric acid were determined in blood serum. The administration of AFB1 caused a decrease in TAS value, the most significant in the rats, which received the highest dose. AFB₁ disturbed the second line of defence against free radicals, which was proved by an increase in the second line defence antioxidant, i.e. uric acid.

Słowa kluczowe

EN

aflatoxin B1; antioxidant status; antioxidative system; mycotoxin; rat; secondary metabolite; blood

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2011
• Tom: 55
• Numer: 1
• Opis fizyczny: p.145-148,ref.

Twórcy

autor

Wojtowicz-Chomicz K.

• Chair and Department of Hygiene, Medical University of Lublin, 20-080 Lublin, Poland

autor

Stadnik A.

autor

Kowal M.

autor

Sztanke K.

autor

Sztanke M.

autor

Borzecki A.

Bibliografia

• 1. Bartosz G.: Second face of the oxygen. Ed. PWN, Warszawa, 2003.
• 2. Bennett J.W., Klich M.: Mycotoxins. Clin Microbiol Rev 2003, 16, 497-516.
• 3. Bonnefoy M., Drai J., Kostka T.: Antioxidants to slow aging, facts and perspectives. Presse Med 2002, 31, 1174- 1184.
• 4. Chełchowska M., Ambroszkiewicz J., Gajewska J., Laskowska-Klita T., Leisbchang J.: Infuence of pregnant women tobacco smoking on uric acid level in mother blood and in newborn umbilical cord blood. Przgl Lek 2007, 64, 10.
• 5. Costa S., Utan A., Speroni E., Cervellati R., Piva G., Prandini A,. Guerra M.C.: Carnosic acid from rosemary extracts: a potential chemoprotective agent against aflatoxin B1. An in vitro study. J Appl Toxicol. 2007, 27, 152-159.
• 6. Drożdż I., Makarewicz M.: Microbiological infection in consumable industry. Lab Przemysłowe 2008, 5, 24-28.
• 7. Duda-Chodak A., Tarko T.: Free radicals - state of art. Laboratorium 2007, 11, 48-50.
• 8. Fossati P., Prencipe L., Berti G.: Use of 3,5-dihloro-2- hydroxybenzenesulfonic acid/4-aminophenazone chromogenic system in direct enzymie assay of uric acid in serum and urine. Clin Chem 1980, 26, 227-231.
• 9. Hellsten Y., Tullson P.C., Richter E.A., Bangsbo J.: Oxidation of urate in human skeletal muscle during exercise. Free Radie Biol Med 1997, 22, 169-174.
• 10. Higutchi Y.: Chromosomal DNA fragmentation in apoptosis and necrosis induced by oxidative stress. Biochem Pharmacol 2003, 66, 1527-1535.
• 11. Kang D.H., Nakagawa T., Feng L., Watanabe S., Han L., Mazzali M., Truong L., Harris R., Johnson R.J.: A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002, 13, 2888-2897.
• 12. Kwiatek K., Kukier E.: Fodder microbiological pollution. Medycyna Wet 2008, 64, 24-26.
• 13. Laciakova A., Ciconova P., Mate D., Laciak V.: Aflatoxins and possibilities for their biological detoxification. Medycyna Wet 2008, 64, 276-279.
• 14. Obremski K., Zielonka Ł., Gajęcka M., Jakimiuk E., Gajęcki M.: Mycotoxins - dairy cattle breeding problem. A case report. Bull Vet Inst Pulawy 2009, 53, 221-224.
• 15. Opara E.C.: Oxidative stress. Dis Mon 2006, 52, 183-198.
• 16. Roche Molecular Biochemicals Enterprise: Uric acid liquid reagent: a tool for your test development. Mannheim, Germany, 2000.
• 17. Rytter S.W., Tyrrell R.M.: Singlet molecular oxygen (¹O₂): a possible effector of eukaryotic gene expression. Free Radic Biol Med 1998, 24, 1520-1534.
• 18. Sivanesan D., Begum V.H.: Preventive role of Gynandropsis gynandra L., against aflatoxin B1 induced lipid peroxidation and antioxidant defense mechanism in rat. India J Exp Biol 2007, 45, 299-303.
• 19. Stec J., Rachubik J., Szczotka M., Kuźmak J.: Effects of penicillium mycotoxins: citrinin, ochratoxin A, and patulin on in vitro proliferation of bovine lymphocytes. Bull Vet Inst Pulawy 2008, 52, 163-167.
• 20. Thefeld W., Hoffmeister H., Busch E.W., Koller P.U., Vollmar J.: Normalwerte der Serumharnsaure in Abhangigkeit von Alter und Geschleht mit einem neuen enzimatischen Harnsaurefarbtest. Dtsch Med Wschr 1973, 98, 380.
• 21. Tulayakul P., Dong K.S., Li J.Y., Manabe N., Kumagai S.: The effect of feeding piglets with the diet containing green tea extracts or coumarin on in vitro metabolism of aflatoxin B1 by their tissues. Toxicon 200, 50, 339-348.
• 22. Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., Telser J.: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2006, 39, 44-84.
• 23. Vrabcheva T.M.: Mycotoxins in spices. Vopr Pitan 2000, 69, 40-43.
• 24. Young D.S.: Effects of drugs on clinical laboratory test. AACC Press, Washington DC, 1995.
• 25. Zabłocka A., Janusz M.: Two faces of oxygen free radicals. Post Hig Med Dośw 2008, 62, 118-124.