Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development

• Autorzy: Markus A. , Yan X. , Rolfs A. , Luo J.
• Języki publikacji: EN

Abstrakty

EN

The ADAM (A Disintegrin and Metalloprotease) family of transmembrane proteins plays important roles in embryogenesis and tissue formation based on their multiple functional domains. In the present study, for the first time, the expression patterns of the premature and the active forms of six members of the ADAM proteins — ADAM9, ADAM10, ADAM12, ADAM17, ADAM22 and ADAM23 — in distinct parts of the developing chicken brain were investigated by quantitative Western blot analysis from embryonic incubation day (E) 10 to E20. The results show that the premature and the active forms of various ADAM proteins are spatiotemporally regulated in different parts of the brain during development, suggesting that the ADAMs play a very important role during embryonic development.

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2011
• Tom: 16
• Numer: 3
• Opis fizyczny: p.431-451,fig.,ref.

Twórcy

autor

Markus A.

• Albrecht-Kossel-Institute for Neuroregeneration, Centre for Mental Health Disease, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany

autor

Yan X.

autor

Rolfs A.

autor

Luo J.

Bibliografia

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