Biologiczne właściwości białek otoczki kuleczek tłuszczowych mleka

• Autorzy: Smoczynski M. , Staniewski B. , Kielczewska K.

Warianty tytułu

EN

Biological activities of milk fat globule membrane proteins

• Języki publikacji: PL

Abstrakty

EN

Milk is a biological fluid considered as an ideal food. However milk not only provides a good balance of all nutrients, but also contains many bioactive compounds fulfilling various functions. One of such components gaining increasing attention in recent years is the milk fat globule membrane. Alongside its primary role in stabilizing lipid globules, it comprises many biologically active molecules. One of such groups are proteins. The primary milk fat globule membrane proteins are: butyrophilin, mucin 1, mucin 15, xanthine dehydrogenase/oxidase (XDH/XO), CD 36, adipophilin, lactadherin and fatty-acid binding protein (FABP). Moreover, many minor proteins with different functions are found in the milk fat globule membrane. In this review biological activities of milk fat globule membrane proteins are described. Unraveling the full composition of the membrane and its impact on the nutritional value of milk should enable the conscious application and use of these bioactive compounds in functional foods.

Słowa kluczowe

PL

mleko; tluszcz mlekowy; kuleczki tluszczowe; otoczki kuleczek tluszczowych; bialka; mucyna; oksydaza ksantynowa; bialko CD36; butyrofilina; adipofilina; wlasciwosci biologiczne

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2011
• Tom: 67
• Numer: 05
• Opis fizyczny: s.313-317,tab.,bibliogr.

Twórcy

autor

Smoczynski M.

• Katedra Mleczarstwa i Zarządzania Jakością, Wydział Nauk o Żywności, Uniwersytet Warmińsko-Mazurski w Olsztynie, ul.Oczapowskiego 7, 10-719 Olsztyn

autor

Staniewski B.

autor

Kielczewska K.

Bibliografia

• 1.Aoki N.: Regulation and functional relevance of milk fat globules and their components in the mammary gland. Biosci. Biotechnol. Biochem. 2006, 70, 2019-2027.
• 2.Berglund L., Petersen T. E., Rasmussen J. T.: Structural characterization of bovine CD36 from the milk fat globule membrane. Biochim. Biophys. Acta 1996, 1309, 63-68.
• 3.Bianchi L., Puglia M., Landi C., Matteoni S., Perini D., Armini A., Verani M., Trombetta C., Soldani P., Roncada P., Greppi G., Pallini V., Bini L.: Solubilization methods and reference 2-DE map of cow milk fat globules. J. Proteomics 2009, 72, 853-864.
• 4.Bickel P. E., Tansey J. T., Welte M. A.: PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochim. Biophys. Acta 2009, 1791, 419-440.
• 5.Bu H. F., Zuo X. L., Wang X., Ensslin M. A., Koti V., Hsueh W., Raymond A. S., Shur B. D., Tan X. D.: Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium. J. Clin. Invest. 2007, 117, 3673-3683.
• 6.Cavaletto M., Giuffrida M. G., Conti A.: The proteomic approach to analysis of human milk fat globule membrane. Clin. Chim. Acta 2004, 347, 41-48.
• 7.Charlwood J., Hanrahan S., Tyldesley R., Langridge J., Dwek M., Camilleri P.: Use of proteomic methodology for the characterization of human milk fat globular membrane proteins. Anal. Biochem. 2002, 301, 314-324.
• 8.Donovan S. M.: Role of human milk components in gastrointestinal development: current knowledge and future needs. J. Pediatr. 2006, 149, 49-61.
• 9.Ensslin M. A., Shur B. D.: The EGF repeat and discoidin domain protein, SED1/MFG-E8, is required for mammary gland branching morphogenesis. Proc. Nat. Acad. Sci. USA 2007, 104, 2715-2720.
• 10.Fong B. Y., Norris C. S., MacGibbon A. K. H.: Protein and lipid composition of bovine milk-fat-globule membrane. Int. Dairy J. 2007, 17, 275-288.
• 11.Girardet J. M., Linden G., Loye S., Courthaudon J. L., Lorient D.: Study of mechanism of lypolysis inhibition by bovine milk proteose-peptone component 3. J. Dairy Sci. 1993, 76, 2156-2163.
• 12.Grenby T. H., Andrews A. T., Mistry M., Williams R. J.: Dental caries-protective agents in milk and milk products: investigations in vitro. J. Dent. 2001, 29, 83-92.
• 13.Hamilton J. A.: How fatty acids bind to proteins: the inside story from protein structures. Prostag. Leukotr. Ess. 2002, 67, 65-72.
• 14.Harrison R.: Milk xanthine oxidas: Properties and physiological roles. Int. Dairy J. 2006, 16, 546-554.
• 15.Heid H. W., Keenan T. W.: Intracellular origin and secretion of milk fat globules. Eur. J. Cell Biol. 2005, 84, 245-258.
• 16.Ischii T., Aoki N., Noda A., Adachi T., Nakamura R., Matsuda T.: Carboxyterminal cytoplasmic domain of mouse butyrophilin specifically associates with a 150-kDa protein of mammary epithelial cells and milk fat globule membrane. Biochim. Biophys. Acta 1995, 1245, 285-292.
• 17.Keenan T. W.: Milk lipid globules and their surrounding membrane: A brief history and perspectives for future research. J. Mammary Gland Biol. 2001, 6, 365-371.
• 18.Kvistgaard A. S., Pallesen L. T., Arias C. F., Lopez S., Petersen T. E., Heegaard C. W., Rasmussen J. T.: Inhibitory effects of human and bovine milk constituents on rotavirus infections. J. Dairy Sci. 2004, 87, 4088-4096.
• 19.LoCascio R. G., Ninonuevo M. R., Freeman S. L., Sela D. A., Grimm R., Lebrilla C. B., Mills D. A., Bruce German J.: Glicoprofiling of bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation. J. Agric. Food Chem. 2007, 55, 8914-8919.
• 20.Mather I. H.: A review and proposed nomenclature for major proteins of the milk-fat globule membrane. J. Dairy Sci. 2000, 83, 203-247.
• 21.Mather I. H., Keenan T. W.: Origin and secretion of milk lipids. J. Mammary Gland Biol. 1998, 3, 259-273.
• 22.McManaman J. L., Russell T. D., Schaack J., Orlicky D. J., Robenek H.: Molecular determinants of milk lipid secretion. J. Mammary Gland Biol. 2007, 12, 259-268.
• 23.Naka M., Kusakabe K., Takeshita A., Nakagawa H., Ito Y., Shibata M. A. Otsuki Y.: Phagocytosis mechanism of apoptotic granulosa cells regulated by milk-fat globule-EGF factor 8. Med. Mol. Morphol. 2009, 42, 143-149.
• 24.Nanga R. P. R., Vivekanandan S., Yoon H. S.: Expression, purification and characterization of C2 domain of milk fat globule-EGF-factor 8-L. Protein Expres. Purif. 2007, 52, 329-333.
• 25.Newburg D. S., Peterson J. A., Ruiz-Palacios G. M., Matson D. O., Morrow A. L., Shults J., de Lourdes Guerrero M., Chaturvedi P., Newburg S. O., Scallan C. D., Taylor M. R., Ceriani R. L., Pickering L. K.: Role of human-milk lactadherin in protection against symptomatic rotavirus infection. Lancet 1998, 351, 1160-1164.
• 26.Ninonuevo M. R., Park Y., Yin H., Zhang J., Ward R. E., Clowers B. H., Bruce German J., Wilson N. L., Robinson L. J., Donnet A., Bovetto L., Packer N. H., Karlsson N. G.: Glycoproteomics of milk: Differences in sugar epitopes on human and bovine milk fat globule membranes. J. Proteome Res. 2008, 7, 3687-3696.
• 27.Ogg S. L., Weldon A. K., Dobbie L., Smith A. J. H., Mather I. H.: Expression of butyrophilin in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Proc. Natl. Acad. Sci. USA 2004, 101, 10084-10089.
• 28.Pallesen L. T., Pedersen L. R. L., Petersen T. E., Rasmussen J. T.: Characterization of carbohydrate structures of bovine MUC15 and distribution of the mucin in bovine milk. J. Dairy Sci. 2007, 90, 3143-3152.
• 29.Patton S., Gendler S. J., Spicer A. P.: The epithelial mucin, MUC1, of milk, mammary gland and other tissues. Biochim. Biophys. Acta 1995, 1241, 407-422.
• 30.Rasmussen J. T.: Bioactivity of milk fat globule membrane proteins. Aust. J. Dairy Technol. 2009, 64, 63-67.
• 31.Reinhardt T. A., Lippolis J. D.: Bovine milk fat globule membrane proteome. J. Dairy Res. 2006, 73, 406-416.
• 32.Riccio P.: The proteins of the milk fat globule membrane in the balance. Trends Food Sci. Tech. 2004, 15, 458-461.
• 33.Shahriar F., Ngeleka M., Gordon J. R., Simko E.: Identification by mass spectroscopy of F4ac-fimbrial-binding proteins in porcine milk and characterization of lactadherin as an inhibitor of F4ac-positive Escherichia coli attachment to intestinal villi in vitro. Dev. Comp. Immunol. 2006, 30, 723-734.
• 34.Singh H.: The milk fat globule membrane - A biophysical system for food applications. Curr. Opin. Colloid Interface Sci. 2006, 11, 154-163.
• 35.Spitsberg V. L.: Bovine milk fat globule membrane as a potential nutraceutical. J. Dairy Sci. 2005, 88, 2289-2294.
• 36.Spitsberg V. L., Gorewitz R. C.: Solubilization and purification of xanthine oxidase from bovine milk fat globule membrane. Protein Expres. Purif. 1998, 13, 229-234.
• 37.Storch J., Thumser A. E. A.: The fatty acid transport function of fatty acid-binding proteins. Biochim. Biophys. Acta 2000, 1486, 28-44.
• 38.Taylor M. R., Peterson J. A., Ceriani R. L., Couto J. R.: Cloning and sequence analysis of human butyrophilin reveals a potential receptor function. Biochim. Biophys. Acta 1996, 1306, 1-4.
• 39.Vanderghem C., Blecker C., Danthine S., Deroanne C., Haubruge E., Guillonneau F., De Pauw E., Francis F.: Proteome analysis of the bovine milk fat globule: Enhancement of membrane purification. Int. Dairy J. 2008, 18, 885-893.
• 40.Walstra P.: Physical chemistry of milk fat globules, [w:] Advanced Dairy Chemistry T. 2: Lipids. Wyd. P.F. Fox, Chapman&Hall, London 1995, 131-178.
• 41.Wilson N. L., Robinson L. J., Donnet A., Bovetto L., Packer N. H., Karlsson N. G.: Glycoproteomics of milk: Differences in sugar epitopes on human and bovine milk fat globule membranes. J. Proteome Res. 2008, 7, 3687-3696.
• 42.Wu C. C., Howell K. E., Neville M. C., Yates III J. R., McManaman J. L.: Proteomics reveal a link between the endoplasmic reticulum and lipid secretory mechanisms in mammary epithelial cells. Electrophoresis 2000, 21, 3470-3482.
• 43.Yang Y., Spitzer E., Kenney N., Zschiesche W., Li M., Kromminga A., Muller T., Spener F., Lezius A., Veerkamp J. H., Smith G. H., Salomon D. S., Grosse R.: Members of the fatty acid binding protein family are differentiation factors for the mammary gland. J. Cell Biol. 1994, 127, 1097-1109.