Genes associated with long-chain omega-3 fatty acids in bovine skeletal muscle

• Autorzy: Perez R. , Canon J. , Dunner S.
• Języki publikacji: EN

Abstrakty

EN

Long-chain omega-3 fatty acids (n-3 FAs) influence meat tenderness, juiciness, and flavor, and are beneficial to human health. The percentage of long-chain n-3 FAs in total FAs is termed the omega-3 index (O3I). It is thus of great interest to favor rising this index in bovine skeletal muscle, to obtain healthier, tastier, and more nutritive meat. This study was aimed to detect transcriptomic variations related to O3I in muscles in 15-month-old males of 4 Spanish cattle breeds raised under the same conditions. Through the analysis of extreme O3I phenotypes, 3 genes of interest (AANAT, UCP2 and AHA1) were identified. AANAT and UCP2 were strongly up-regulated, while AHA1 was repressed in animals with a high 031. Moreover, gene expression differed between GDFS-null animal muscles (tested for nt821del11 and Q204X mutations) and the wild-type muscles for genes GDH1, IGF2R, FADS1, ASPH, and AIM1, all showing down-regulation in Asturiana de los Valles calves with muscle hypertrophy (GDF8-null). This shows that in GDF8-null animals other pathways are used for FA synthesis.

Słowa kluczowe

EN

differential display; lipid metabolism; long-chain fatty acid; meat quality; omega-3 fatty acid; bovine skeletal muscle; skeletal muscle; meat tenderness; human health; gene expression; dietary fat; lipid; dietetic value

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 2010
• Tom: 51
• Numer: 4
• Opis fizyczny: p.479-487,ref.

Twórcy

autor

Perez R.

• Department of Animal Production, Veterinary Faculty, Complutense University of Madrid, Spain

autor

Canon J.

• Department of Animal Production, Veterinary Faculty, Complutense University of Madrid, Spain

autor

Dunner S.

• Department of Animal Production, Veterinary Faculty, Complutense University of Madrid, Spain

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