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2010 | 66 | 09 |

Tytuł artykułu

Chłoniak u psa - aspekty diagnostyki klinicznej

Warianty tytułu

EN
Lymphoma in a dog - practical aspects of diagnosis

Języki publikacji

PL

Abstrakty

EN
Lymphomas, which originate from various forms of lymphocytes, are the most common hematological malignancies in dogs. Their etiology is complicated because of the lack of clearly identified pathological factors. In the current WHO classification there are three main groups of tumors: B-cell lymphomas, lymphomas with T and NK cells and Hodgkin’s disease. Lymphomas originating from B cell lines represent about 80 percent of non-Hodgkin lymphomas. This paper presents our experiences in the diagnostics of lymphadenopathy. A 7-year-old male dog was brought to hospital because of a generalized enlargement of lymph nodes. Diagnostic procedures performed on the dog included a clinical examination, laboratory examinations of blood, ECG, X-ray and ultrasound examinations, two aspiration biopsies (FNAB) as well as a histopathological examination of a lymph node. Lymphoma therapy was administered in accordance with the COP chemotherapy protocol. Results of the clinical examination and laboratory tests confirmed the diagnosis of B-cell malignant lymphoma - lymphoblastic type. Lymphoma diagnostics are based on cytological and histopathological examinations and the cell proliferation ratio. The phenotype of the lymphoma is important for prognosis. The use of specific antibodies for the identification of CD surface antigens, including certain cell lines, is helpful in the diagnosis. The longest period of survival and control of the disease can be obtained by treatment with doxorubicin combined with simultaneous radiotherapy. In the case of recurrence, dacarbazine (DTIC) therapy is effective.

Wydawca

-

Rocznik

Tom

66

Numer

09

Opis fizyczny

s.635-639,fot.,tab.,bibliogr.

Twórcy

  • Katedra i Klinika Chorób Wewnętrznych Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul.Głęboka 30, 20-612 Lublin
autor
autor

Bibliografia

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  • 2. Bauer N. B., Zervos D., Moritz A.: Argyrophilic nucleolar organizing regions and Ki67 equally reflect proliferation in fine needle aspirates of normal, hyperplastic, inflamed, and neoplastic canine lymph nodes (n = 101). J. Vet. Intern. Med. 2007, 21, 928-935.
  • 3. Chun R.: Lymphoma: Which chemotherapy protocol and why? Top Companion Anim. Med. 2009, 24, 157-162.
  • 4. Chung J. S., Shin H. J., Lee E. Y., Ho G. J.: Hypersensivity to mosquito bites associated with natural killer-derived large granular lymphocyte lymphocytosis: a case report in Korea. The Korean J. Intern. Med. 2003, 18, 50-52.
  • 5. De Zang G., Zappuli V., Cavicchioli L., Di Martino L., Ros E., Conforto G., Costagnaro M.: Gastric B-cell lymphoma with Mott cell differentiation in a dog. J. Vet. Diagn. Invest. 2009, 21, 715-719.
  • 6. Dickinson R. M.: Canine lymphosarcoma: overcoming diagnostic obstacles and introduction to the latest diagnostic techniques. Can. Vet. J. 2008, 49, 305-308.
  • 7. Duncan A. W., Marr H. S., Birkenheuer A. J., Maggi R. G., Williams L. E., Correa M. T., Breitschwerdt E. B.: Bartonella DNA in the blood and lymph nodes of Golden Retrievers with lymphoma and in healthy controls. J. Vet. Intern. Med. 2008, 22, 89-95.
  • 8. Fan T. M., De Lorimier L.: Leczenie chłoniaków u psów i kotów. Wet. po Dyplomie 2006, 7, 16-22.
  • 9. Griessmayr P., Payne S., Winter J., Barber L. G., Shofer F.: Dacarbazine as a single-agent therapy for relapsed lymphoma in dogs. J. Vet. Intern. Med. 2009, 23, 1227-1231.
  • 10. Ho C. L., Hwang L. L.: Structure and biological activities of a new mastoparan isolated from the venom of the hornet Vespa basalis. Biochem. J. 1991, 274, 453-456.
  • 11. Jubala C. M., Wojcieszyn J. W., Valli V. E. O., Getzy D. M., Fosmire S. P., Coffey D., Bellgrau D., Modiano J. F.: CD20 Expression in Normal Canine B Cells and in Canine non-Hodgkin Lymphoma. Vet. Pathol. 2005, 42, 468-476.
  • 12. Jurczak W., Walewski J.: Chłoniak z komórek płaszcza - optymalne podejście do leczenia w świetle badań klinicznych. Onkologia Prak. Klin. 2007, 5, 254-258.
  • 13. Kaneko N., Tanimoto T., Marimoto M., Hayashi T., Shimokawa Miyama T., Hiraoka H., Itamoto K., Une S., Mizuno T., Okuda M.: Use of formalin-Fixed Paraffin-Embded Tissue and single-strand conformation polymorphism analysis for polymerase chain reaction of antigen receptor rearrangements in dogs. J. Vet. Med. Sci. 2009, 71, 535-538.
  • 14. Kunitomi A., Konaka Y., Yagita M.: Hypersensitivity to mosquito bites as a potential sign of mantle cell lymphoma. Intern. Medicine 2005, 44, 1097-1099.
  • 15. Lobetti R. G.: Lymphoma in 3 related Rottweilers from a single hausehold. J. S. Afr. Vet. Assoc. 2009, 80, 103-105.
  • 16. Madej J. A.: Chłoniaki złośliwe nieziarnicze u psów. Medycyna Wet. 2003, 59, 371-375.
  • 17. Magnol J. P., Guelfi J. F.: Color Atlas of Cancer Cytology of the Dog and Cat. Confére. National des Vétérinaires Spécialisés en Petits Animaux, Paris 1994, 258-262.
  • 18. Marconato L., Crispiano G., Finotello R., Mazzotti S., Salerni F., Zini E.: Serum lactate dehydrogenase activity in canine malignancies. Vet. Comp. Oncol. 2009, 7, 236-243.
  • 19. Morris J., Dobson J.: Onkologia małych zwierząt. SIMA WLW, Warszawa 2003, 230-241.
  • 20. Nielsen L., Toft N., Eckersall P., Mellor D., Morris J.: Serum C-reactive protein concentration as an indicator of remission status in dogs with multicentric lymphoma. J. Vet. Intern. Med. 2007, 21, 1231-1236.
  • 21. Saba C., Hafeman S., Vail D., Thamm D.: Combination chemotherapy with continuous L-asparaginas, lomustine and prednisone for relapsed canine lymphoma. J. Vet. Intern. Med. 2009, 23, 1058-1063.
  • 22. Sandbank M., Barr-Nea L., Ishay J.: Pseudolymphoma of skin induced by oriental hornet (Vespa orientalis) venom ultrastructural study. Arch. Dermatol. Res. 1978, 262, 135-141.
  • 23. Sapierzyński R., Sokołowska J.: Cytologiczna diagnostyka chłoniaków u psów. Medycyna Wet. 2008, 64, 872-876.
  • 24. Wakimoto N., Nitsu N.: Lymphoid Neoplasm associated with mosquito bites. Intern. Medicine 2005, 44, 1118-1119.

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Bibliografia

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