Personal remarks on the future of protein crystallography and structural biology

• Autorzy: Jaskolski M.
• Języki publikacji: EN

Abstrakty

EN

Protein crystallography, the main experimental method of structural biology, has undergone in the recent past three revolutionary changes leading to its unexpected renaissance. They were connected with (i) the introduction of synchrotron radiation sources for X-ray diffraction experiments, (ii) implementation of Se-Met multiwavelength anomalous diffraction (MAD) for phasing, and (iii) initiation of structural genomics (SG) programs. It can be foreseen that in the next 10-15 years protein crystallography will continue to be in this revolutionary phase. We can expect not only an; avalanche of protein crystal structures from SG centers, but also attacking of more demanding projects, such as the structure of membrane proteins and of very large macromolecular complexes. On the technological front, the introduction of X-ray radiation from free-electron lasers will revolutionize the experimental possibilities, making feasible even the imaging of single molecules and of intact biological cells.

Słowa kluczowe

EN

structural genomics; future; protein crystallography; structural biology; genomics; synchrotron radiation; X-ray free electron laser; X-ray radiation; molecule; biological cell

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2010
• Tom: 57
• Numer: 3
• Opis fizyczny: p.261-264,ref.

Twórcy

autor

Jaskolski M.

• Department of Crystallography, Faculty of Chemistry, Adam Mickiewicz University, and Center of Biocrystallographic Research Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland

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