Pain and mobility improvement and MDA plasma levels in degenerative osteoarthritis, low back pain, and rheumatoid arthritis after infrared A-irradiation

• Autorzy: Siems W. , Bresgen N. , Brenke R. , Siems R. , Kitzing M. , Harting H. , Eckl P. M.
• Języki publikacji: EN

Abstrakty

EN

 Infrared (IR)-A irradiation can be useful in back and musculoskeletal pain therapy. In this study joint and vertebral column pain and mobility were measured during two weeks of IR-A irradiation treatment of patients suffering from degenerative osteoarthritis of hip and knee, low back pain, or rheumatoid arthritis. Additionally, before and after IR-A treatment MDA serum levels were measured to check if MDA variations accompany changes in pain intensity and mobility. Two-hundred and seven patients were divided into verum groups getting IR-irradiation, placebo groups getting visible, but not IR irradiation, and groups getting no irradiation. In osteoarthritis significant pain reduction according to Visual Analogue Scale and mobility improvements occurred in the verum group. Even though beneficial mean value changes occurred in the placebo group, the improvements in the placebo and No Irradiation groups were without statistical significance. In low back pain, pain and mobility improvements (by 35-40 %) in the verum group were found, too. A delayed (2nd week) mobility improvement in rheumatoid arthritis was seen. However, pain relief was seen immediately. In patients suffering from low back pain or rheumatoid arthritis, the pain and mobility improvements were accompanied by significant changes of MDA serum levels. However, MDA appears not a sensitive biofactor for changes of the pain intensity in degenerative osteoarthritis. Nevertheless, unaffected or lowered MDA levels during intensive IR-A therapy argue against previous reports on free radical formation upon infrared. In conclusion, rapid beneficial effects of IR-A towards musculoskeletal pain and joint mobility loss were demonstrated.

Słowa kluczowe

EN

pain; mobility improvement; malondialdehyde; plasma level; degenerative osteoarthritis; low back pain; osteoarthritis; rheumatoid arthritis; infrared A-irradiation; infrared radiation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2010
• Tom: 57
• Numer: 3
• Opis fizyczny: p.313-319,fig.,ref.

Twórcy

autor

Siems W.

• KortexMed Bad Harzburg, Research Institute of Physiotherapy and Gerontology, Bad Harzburg, Germany

autor

Bresgen N.

autor

Brenke R.

autor

Siems R.

autor

Kitzing M.

autor

Harting H.

autor

Eckl P. M.

Bibliografia

• Bagis S, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, Erdogan C (2005) Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? Rheumatol Int 25: 188-190. 
• Baronzio G, Gramaglia A, Fiorentini G (2006) Hyperthermia and immunity. In Vivo 20: 689-695. 
• Gil L, Siems W, Mazurek B, Gross J, Schroeder P, Voss P, Grune T (2006) Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes. Free Radic Res 40: 495-505. 
• Gruenberger P (2007) Oxidativer Stress bei thermischen Ganzkörperreizen - Sauna im Vergleich zum Winterschwimmen M.D. Dissertation, Humboldt UniversityPress, Berlin.
• Hammond A (2004) Rehabilitation in rheumatoid arthritis: a critical review. Musculoskeletal Care 2: 135-151. 
• Hardy JD, Goodell H, Wolff HG (1951) The influence of skin temperature upon the pain threshold as evoked by thermal radiation. Science 114: 149-150. 
• Khanapure SP, Garvey DS, Janero DR, Letts LG (2007) Eicosanoids in inflammation: biosynthesis, pharmacology, and therapeutic frontiers. Curr Top Med Chem 7: 311-340. 
• Kukkonen-Harjula K, Kauppinen K (2006) Health effects and risks of sauna bathing. Int J Circumpolar Health 65: 195-205. 
• Masuda A, Koga Y, Hattanmaru M, Minagoe S, Tei C (2005) The effects of repeated thermal therapy for patients with chronic pain. Psychother Psychosom 74: 288-294. 
• Merskey H, Watson GD (1979) The lateralisation of pain. Pain 7: 271-280. 
• Merskey H (1989) Psychiatry and chronic pain. Can J Psychiatry 34: 329-336. 
• Moriyama T, Higashi T, Togashi K, Iida T, Segi E, Sugimoto Y, Tominaga T, Narumiya S, Tominaga M (2005) Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain 1: 3. 
• Ozgocmen S, Ozyurt H, Sogut S, Akyol O, Ardicoglu O, Yildizhan H (2006) Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns. Rheumatol Int 26: 598-603. 
• Perret DM, Rim J, Cristian A (2006) A geriatrician's guide to the use of the physical modalities in the treatment of pain and dysfunction. Clin Geriatr Med 22: 331-354. 
• Piazena H (2002) Nutzung künstlich erzeugter Infrarot-Strahlung für Prophylaxe und Wellness - Grundlagen, Grenzwerte und Qualitätskontrolle. Saunabetr Baederpraxis 1: 13-17.
• Pulichino AM, Rowland S, Wu T, Clark P, Xu D, Mathieu MD, Riendeau D, Audoly LP (2006) Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis. J Pharmacol Exp Ther 319: 1043-1050. 
• Rokyta R, Holecek V, Pekarkova I, Krejcova J, Racek J, Trefil L, Yamamotova A (2003) Free radicals after painful stimulation are influenced by antioxidants and analgesics. Neuro Endocrinol Lett 24: 304-309. 
• Rosseland LA, Krohn CD, Stubhaug A (2007) Synovial fluid concentration of prostaglandin E2 correlates with pain intensity after knee arthroscopic procedures. Anesth Analg 104: 460-461. 
• Schroeder P, Lademann J, Darvin ME, Stege H, Marks C, Bruhnke S, Krutmann J (2008) Infrared radiation-induced matrix metalloproteinase in human skin: implications for protection. J Invest Dermatol 128: 2491-2497. 
• Schroeder P, Pohl C, Calles C, Marks C, Wild S, Krutmann J (2007) Cellular response to infrared radiation involves retrograde mitochondrial signalling. Free Radic Biol Med 43: 128-135. 
• Siems WG, Hapner SH, van Kuijk F (1996) 4-Hydroxynonenal inhibits Na+-K+-ATPase. Free Radic Biol Med 20: 215-223. 
• Siems W, Capuozzo E, Lucano A, Salerno C, Crifò C (2003) High sensitivity of plasma membrane ion transport ATPases from human neutrophils towards 4-hydroxy-2,3-trans-nonenal. Life Sciences 73: 2583-2590. 
• Smith HS (2006) Arachidonic acid pathways in nociception. J Support Oncol 4: 277-287. 
• Sommerburg O, Grune T, Klee S, Ungemach FR, Siems WG (1993) Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromo-trichloromethane treatment of rat liver cells. Mediators Inflamm 2: 27-31. 
• Sondik EJ, Madans JH, Sadagursky MH (2005) Vital and Health Statistics Series 10, no. 225, Summary Health Statistics for U.S. Adults: National Health Interview Survey 2003, National Center for Health Statistics, Hyatsville, Maryland, DHHS Publication No. (PHS) 2005 1553: 1-151.
• Stelian J, Gil I, Habot B, Rosenthal M, Abramovici I, Kutok N, Khahil A (1992) Improvement of pain and disability in elderly patients with degenerative osteoarthritis of the knee treated with narrow-band light therapy. J Am Geriatr Soc 40: 23-26. 
• Stewart WG, Ricci JA, Chee W, Morganstein D, Lipton R (2003) Lost productive time and cost due to common pain conditions in the US workforce. JAMA 290: 2443-2454. 
• Wong SHJ, Knight JA, Hopfer SM, Zaharia O, Leach CN, Sunderman FW (1987) Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem 33: 214-220. 
• Wuelker N (2005) Orthopaedics and traumatological surgery. Georg Thieme Verlag, Stuttgart, New York.