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2009 | 69 | 3 |
Tytuł artykułu

Metabotropic glutamate receptor ligands as a possible targets for treatment of anxiety and depression

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Preclinical data indicated that antagonists of group I mGlu receptors, particularly antagonists of mGlu5 receptors, produced both anxiolytic-like and antidepressant-like effects. Clinical data also demonstrated that mGlu5 receptor antagonist, fenobam, was an active anxiolytic drug. The anxiolytic effects exerted by mGlu5 receptor antagonists are profound, comparable to or stronger than those of benzodiazepines. Among all mGlu receptor ligands, group II mGlu receptor agonists seem to be drugs with promising therapeutic potential and good safety profi le. Animal studies showed anxiolytic-like effects of group II mGlu receptor agonists. Currently, group II mGlu receptor agonists are in phase III clinical trials for potential treatment of anxiety disorders. On the other hand, data have been accumulated indicating that antagonists of group II mGlu receptors have an antidepressant potential. Group III mGlu receptor ligands represent the least investigated group of mGlu receptors. The preclinical data, however, indicate that a selective agonist of mGlu4 and Glu8 receptors- ACPT-I produced anxiolytic but not antidepressant effects after peripheral administration, while the selective positive allosteric modulator of Glu7 receptors, AMN082 produced both anxiolytic and antidepressantlike. The data show that the effects of group III mGlu receptor ligands may differ dependently of their receptor subtype specifi city
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.288
Twórcy
autor
  • Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
  • Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
  • Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
autor
  • Department of Neurobiology, Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-fb492f39-69c2-46d7-a9eb-c633aa80676f
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