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2009 | 69 | 3 |
Tytuł artykułu

Parkinson's disease leads to distorted interaction of episodic and working memory systems

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Patients with Parkinson’s disease (PD) exhibit impairments in executive function and working memory. As opposed to motor symptoms of the disease the physiological origins of cognitive defi cits are not well understood. The aim of the present study was to delineate mechanisms of cognitive impairment in PD using blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI). Twenty-two patient and 10 matched control subjects accomplished Wisconsin Card Sorting Test (WCST) – standard clinical measure of executive function and then underwent fMRI during performance of the N-Back working memory task.The correlation analysis comparing BOLD signal intensity changes with number of categories achieved in WCST revealed a signifi cant positive correlation within supramarginal gyrus, inferior parietal gyrus, middle and inferior frontal gyrus and caudate nucleus. Signifi cant negative correlations with executive impairment were observed within fusiform and parahippocampal gyrus, as well as enthorhinal and perirhinal cortex. These results suggest that cognitive impairment in PD may origin in consequence of distorted interaction between episodic and working memory systems.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.344
Twórcy
autor
  • Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
  • Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
  • Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
  • Warsaw University of Technology, Institute of Radioelectronic, Warsaw, Poland
  • Warsaw University of Technology, Institute of Radioelectronic, Warsaw, Poland
autor
  • Institute of Physiology and Pathology of Hearing, Warsaw, Poland
autor
  • Medical University of Warsaw, Warsaw, Poland
  • Medical University of Warsaw, Warsaw, Poland
  • Medical University of Warsaw, Warsaw, Poland
autor
  • Medical University of Warsaw, Warsaw, Poland
autor
  • Medical University of Warsaw, Warsaw, Poland
autor
  • Medical University of Warsaw, Warsaw, Poland
autor
  • Medical University of Warsaw, Warsaw, Poland
autor
  • Medical University of Warsaw, Warsaw, Poland
autor
  • Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-f73c7f16-da34-46fc-bdef-ebf61b5b44f8
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