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2009 | 69 | 3 |
Tytuł artykułu

Nuclear betta-catenin is constitutively present in thalamic neurons

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Wnt signaling is one of the most important mechanisms engaged in embryonic development. In the adult organism it is present in regenerating tissues. The key mediator in the signaling is β-catenin, which translocates to the nucleus and triggers transcription of the Lef1/Tcf target genes. Recently, expression of some of the Wnt pathway components has been observed in the thalamus of the adult brain. We show that β-catenin and Lef1 are constitutively present in nuclei of thalamic neurons in vivo. We also demonstrate that β-catenin accumulates in about 40% of thalamic cells in vitro, without any prior stimulation. This phenomenon does not depend on soluble factors produced by glia cells or cortical neurons, because nor glia cells co-culture neither cortical conditioned medium affects the number of β-catenin positive cells. These observations support a new idea that Wnt/β-catenin signaling is an intrinsic feature of thalamic neurons, independent on thalamo-cortical interaction what was proposed before. Whether the nuclear localization of β-catenin in thalamic neurons is a consequence of autocrine Wnt stimulation or a specifi c regulation inside the cells remains to be determined.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
69
Numer
3
Opis fizyczny
p.299
Twórcy
autor
  • Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warsaw, Poland
  • Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warsaw, Poland
autor
  • Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warsaw, Poland
  • Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
autor
  • Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warsaw, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-f51d9f48-e33d-47b8-b369-6600766cfef5
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